Introduction：Basic information about CAS 537705-08-1|CP-724714, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CP-724714 |
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| CAS Number | 537705-08-1 | Molecular Weight | 469.535 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 687.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C27H27N5O3 | Melting Point | / |
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| MSDS | / | Flash Point | 369.5±31.5 °C |
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Names
| Name | (E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate |
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| Synonym | More Synonyms |
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CP-724714 BiologicalActivity
| Description | (E/Z)-CP-724714 is a racemic compound of (E)-CP-724714 and (Z)-CP-724714 isomers. CP-724714 is a potent and selective orally active ErbB2 (HER2) inhibitor[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFR |
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| Target | HER2 |
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| References | [1]. Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 687.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C27H27N5O3 |
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| Molecular Weight | 469.535 |
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| Flash Point | 369.5±31.5 °C |
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| Exact Mass | 469.211395 |
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| PSA | 98.26000 |
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| LogP | 4.05 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.663 |
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| Storage condition | -20°C |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Kumarin |
| 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide |
| Rattex |
| CUMARIN |
| (E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate |
| COUMARINE |
| chromen-2-one |
| 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide |
| 2-Methoxy-N-{(2E)-3-[4-({3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl}amino)-6-quinazolinyl]-2-propen-1-yl}acetamide |
| Acetamide, 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]- |
