Introduction：Basic information about CAS 122520-85-8|AG 99, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AG 99 |
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| CAS Number | 122520-85-8 | Molecular Weight | 204.182 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 544.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C10H8N2O3 | Melting Point | 231 °C |
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| MSDS | / | Flash Point | 283.0±30.1 °C |
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Names
| Name | 2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide |
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| Synonym | More Synonyms |
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AG 99 BiologicalActivity
| Description | (E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) is a potent EGFR inhibitor[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFR |
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| Target | EGFR |
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| References | [1]. Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 544.4±50.0 °C at 760 mmHg |
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| Melting Point | 231 °C |
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| Molecular Formula | C10H8N2O3 |
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| Molecular Weight | 204.182 |
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| Flash Point | 283.0±30.1 °C |
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| Exact Mass | 204.053497 |
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| PSA | 107.34000 |
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| LogP | 0.02 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.711 |
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| Storage condition | Desiccate at +4°C |
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Synonyms
| 3,4-dihydroxybenzalcyanoacetamide |
| IN1036 |
| Tyrphostin A46 |
| 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- |
| (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide |
| Tyrphostin AG 99 |
| HMS3266G04 |
| (E)-2-Cyano-3-(3,4-Dihydroxyphenyl)Prop-2-Enamide |
| (E)-AG 99 |
