CAS 1219795-47-7|Nisoldipine-d4

Introduction：Basic information about CAS 1219795-47-7|Nisoldipine-d4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameNisoldipine-d4
CAS Number1219795-47-7Molecular Weight392.43900
Density/Boiling Point/
Molecular FormulaC20H20D4N2O6Melting Point/
MSDS/Flash Point/

Names

NameNisoldipine-d4

Nisoldipine-d4 BiologicalActivity

DescriptionNisoldipine-d4 (BAY-k 5552-d4) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].
Related CatalogSignaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease
In VitroStable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Hamilton SF, Houle LM, Thadani U. Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure. Heart Dis. 1999 Nov-Dec;1(5):279-88.

[3]. Fodor JG. Nisoldipine CC: efficacy and tolerability in hypertension and ischemic heart disease. Cardiovasc Drugs Ther. 1997 Jan;10 Suppl 3:873-9.

[4]. D.J. Duncker, J.M. Hartog, P.G. Hugenholtz, et al. The effects of nisoldipine (Bay K 5552) on cardiovascular performance and regional blood flow in pentobarbital - anaesthetized pigs with or without β-adrenoceptor blockade. British Journal of Pharmacology. 1986,88(1): 9-18

[5]. Jan W. De Jong, Tom Huizer, Jan G.P. Tijssen. Energy conservation by nisoldipine in ischaemic heart. British Journal of Pharmacology. 1984, 83(4): 943-949

Chemical & Physical Properties

Molecular FormulaC20H20D4N2O6
Molecular Weight392.43900
Exact Mass392.18900
PSA110.45000
LogP4.05380
InChIKeyVKQFCGNPDRICFG-YKVCKAMESA-N
SMILESCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]
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