Introduction：Basic information about CAS 117488-23-0|TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID |
|---|
| CAS Number | 117488-23-0 | Molecular Weight | 159.14000 |
|---|
| Density | 1.568g/cm3 | Boiling Point | 288.1ºC at 760mmHg |
|---|
| Molecular Formula | C6H9NO4 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 128ºC |
|---|
Names
| Name | 1-aminocyclobutane-cis-1,3-dicarboxylic acid |
|---|
| Synonym | More Synonyms |
|---|
BiologicalActivity
| Description | trans-ACBD (trans-1-Aminocyclobutane-1,3-dicarboxylic acid) is a very potent and selective NMDA receptor agonist that modulates glutamatergic neurotransmission[1]. |
|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
|---|
| References | [1]. Dimpfel W, et al. Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro. BMC Pharmacol. 2011 Feb 21;11:2. |
|---|
Chemical & Physical Properties
| Density | 1.568g/cm3 |
|---|
| Boiling Point | 288.1ºC at 760mmHg |
|---|
| Molecular Formula | C6H9NO4 |
|---|
| Molecular Weight | 159.14000 |
|---|
| Flash Point | 128ºC |
|---|
| Exact Mass | 159.05300 |
|---|
| PSA | 100.62000 |
|---|
| Vapour Pressure | 0.000607mmHg at 25°C |
|---|
| Index of Refraction | 1.587 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GU1690000
- CHEMICAL NAME :
- 1,3-Cyclobutanedicarboxylic acid, 1-amino-, trans-, hydrate
- CAS REGISTRY NUMBER :
- 117488-23-0
- LAST UPDATED :
- 199109
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C6-H9-N-O4.H2-O
- MOLECULAR WEIGHT :
- 177.18
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2905,1990
|
Synonyms
| trans-1-aminocyclobutane-1,3-dicarboxylic acid |
| cis-2,4-methanoglutamate |
| 1-aminocyclobutyl carboxylic acid methyl ester |
| 1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER |
| trans-2,4-methanoglutamic acid |
| methyl 1-amino-cyclobutanecarboxylate |
