Introduction：Basic information about CAS 118803-81-9|quinoline-3-carboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | quinoline-3-carboxylic acid |
|---|
| CAS Number | 118803-81-9 | Molecular Weight | 442.440 |
|---|
| Density | / | Boiling Point | 555.8ºC at 760 mmHg |
|---|
| Molecular Formula | C22H23FN4O5 | Melting Point | 277-280ºC(lit.) |
|---|
| MSDS | / | Flash Point | 289.9ºC |
|---|
Names
| Name | 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,pyridine-3-carboxylic acid |
|---|
| Synonym | More Synonyms |
|---|
quinoline-3-carboxylic acid BiologicalActivity
| Description | Norfloxacin nicotinate (MK-0366 nicotinate) is a fluoroquinolones antibiotic, an adduct of Norfloxacin (NOR) and nicotinic acid. Norfloxacin nicotinate has been widely used for replacing NOR in animal husbandry and fishery industry. Norfloxacin nicotinate can induce innate immune response at a high concentration[1]. |
|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
|---|
| In Vivo | Norfloxacin nicotinate (5 and/or 25 mg/L) significantly induces antioxidant enzymes activities and the mRNA levels of genes related to antioxidant enzymes and innate immune system in zebrafish larvae[1]. |
|---|
| References | [1]. Liang X, et al. Effects of norfloxacin nicotinate on the early life stage of zebrafish (Danio rerio): Developmental toxicity, oxidative stress and immunotoxicity. Fish Shellfish Immunol. 2020 Jan;96:262-269. |
|---|
Chemical & Physical Properties
| Boiling Point | 555.8ºC at 760 mmHg |
|---|
| Melting Point | 277-280ºC(lit.) |
|---|
| Molecular Formula | C22H23FN4O5 |
|---|
| Molecular Weight | 442.440 |
|---|
| Flash Point | 289.9ºC |
|---|
| Exact Mass | 442.165253 |
|---|
| PSA | 124.76000 |
|---|
| LogP | 2.44190 |
|---|
| Vapour Pressure | 3.45E-13mmHg at 25°C |
|---|
| InChIKey | WRIFLTAYLRDENF-UHFFFAOYSA-N |
|---|
| SMILES | CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21.O=C(O)c1cccnc1 |
|---|
Safety Information
| Safety Phrases | S22 |
|---|
| WGK Germany | 3 |
|---|
Synonyms
| 3-Pyridinecarboxylic acid, compd. with 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (1:1) |
| Norfloxacin nicotinate |
| 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid - nicotinic acid (1:1) |
| 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid - nicotinic acid (1:1) |
