CAS 120210-48-2|CP-66248
| Common Name | CP-66248 | ||
|---|---|---|---|
| CAS Number | 120210-48-2 | Molecular Weight | 320.75 |
| Density | 1.58g/cm3 | Boiling Point | 523.9ºC at 760mmHg |
| Molecular Formula | C14H9ClN2O3S | Melting Point | 230° (dec) |
| MSDS | ChineseUSA | Flash Point | 270.7ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | tenidap |
|---|---|
| Synonym | More Synonyms |
CP-66248 BiologicalActivity
| Description | Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
| Target | COX-1:0.03 μM (IC50) COX-2:1.2 μM (IC50) |
| References | [1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38(10):1447-56. |
Chemical & Physical Properties
| Density | 1.58g/cm3 |
|---|---|
| Boiling Point | 523.9ºC at 760mmHg |
| Melting Point | 230° (dec) |
| Molecular Formula | C14H9ClN2O3S |
| Molecular Weight | 320.75 |
| Flash Point | 270.7ºC |
| Exact Mass | 320.00200 |
| PSA | 111.87000 |
| LogP | 4.01840 |
| Appearance of Characters | faint yellow to dark yellow |
| Vapour Pressure | 7.42E-13mmHg at 25°C |
| Index of Refraction | 1.756 |
| InChIKey | IZSFDUMVCVVWKW-UHFFFAOYSA-N |
| SMILES | NC(=O)n1c(O)c(C(=O)c2cccs2)c2cc(Cl)ccc21 |
| Storage condition | Store at +4°C |
| Water Solubility | DMSO: soluble1mg/mL, clear (warmed) |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
Articles28
More Articles| Tenidap decreases IL-8 and monocyte chemotactic peptide-1 (MCP-1) mRNA expression in the synovial tissue of rabbits with antigen arthritis and in cultured synovial cells. Clin. Exp. Immunol. 111(3) , 588-96, (1998) Since IL-8 and MCP-1 are chemoattractant proteins that participate in the recruitment of inflammatory cells into the arthritic joint, we examined the effects of tenidap, a new anti-inflammatory drug o... | |
| The renal Na-HCO3-cotransporter expressed in Xenopus laevis oocytes: inhibition by tenidap and benzamil and effect of temperature on transport rate and stoichiometry. Pflugers Arch. 442(5) , 709-17, (2001) In the present experiments we expressed the rat kidney Na+-HCO3- cotransporter (rkNBC) in Xenopus laevis oocytes to reinvestigate the flux coupling ratio under improved measuring conditions. Essential... | |
| Tenidap: not just another NSAID? Ann. Rheum. Dis. 55(2) , 79-82, (1996) |
Synonyms
| TENIDAP |
| Tenidapum |
| (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-carboxamide |
| IL-6+Tenidap |
| (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide CP 66248 |
