Introduction：Basic information about CAS 122647-31-8|IBUTILIDE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | IBUTILIDE |
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| CAS Number | 122647-31-8 | Molecular Weight | 384.57600 |
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| Density | 1.099g/cm3 | Boiling Point | 522.4ºC at 760mmHg |
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| Molecular Formula | C20H36N2O3S | Melting Point | / |
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| MSDS | / | Flash Point | 269.7ºC |
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Names
| Name | ibutilide |
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| Synonym | More Synonyms |
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IBUTILIDE BiologicalActivity
| Description | Ibutilide (U70226E free base), an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| In Vitro | Ibutilide is a potent IKr blocker with EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells[1]. Ibutilide blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC50: 22.5±0.9 vs 27.4±2.5 nM). However, cells expressing MDR1*7 show a marked resistance to Ibutilide (IC50: 105.3±1.42 nM vs 27.4±2.5 nM)[2]. |
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| In Vivo | Ibutilide prolongs cardiac repolarization in vitro and in vivo[1]. Ibutilide infusions (administered cumulatively in three doses, 0.01, 0.02 and 0.05 mg/kg i.v., each as a 10-min infusion) results in both polymorphic and monomorphic non-sustained ventricular tachycardia[3]. Animal Model: Fifteen adult mongrel dogs of either sex[1] Dosage: 0.01, 0.02 and 0.05 mg/kg Administration: Infusion Result: The action potential duration at 90% (APD90) prolongation with Ibutilide (0.01 mg/kg) was significantly greater in congestive heart failure (CHF) vs. controls. An increased dispersion of left–right ventricular APD90 was observed in CHF at 0.01 mg/kg, but not in controls. |
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| References | [1]. Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995 Mar 15;91(6):1799-806. [2]. B F McBride, et al. Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and Ibutilide-induced block of HERG. Pharmacogenomics J. 2009 Jun;9(3):194-201. [3]. S S Chugh, et al. Altered response to Ibutilide in a heart failure model. Cardiovasc Res. 2001 Jan;49(1):94-102. |
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Chemical & Physical Properties
| Density | 1.099g/cm3 |
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| Boiling Point | 522.4ºC at 760mmHg |
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| Molecular Formula | C20H36N2O3S |
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| Molecular Weight | 384.57600 |
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| Flash Point | 269.7ºC |
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| Exact Mass | 384.24500 |
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| PSA | 78.02000 |
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| LogP | 5.31780 |
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| Vapour Pressure | 9.71E-12mmHg at 25°C |
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| InChIKey | ALOBUEHUHMBRLE-UHFFFAOYSA-N |
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| SMILES | CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1 |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R22 |
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Synonyms
