Introduction：Basic information about CAS 194093-42-0|Pumosetrag Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pumosetrag Hydrochloride |
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| CAS Number | 194093-42-0 | Molecular Weight | 339.840 |
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| Density | / | Boiling Point | 529.9ºC at 760mmHg |
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| Molecular Formula | C15H18ClN3O2S | Melting Point | / |
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| MSDS | USA | Flash Point | 274.3ºC |
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Names
| Name | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-oxo-4H-thieno[3,2-b]pyridine-6-carboxamide,hydrochloride |
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| Synonym | More Synonyms |
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Pumosetrag Hydrochloride BiologicalActivity
| Description | Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Metabolic Disease |
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| Target | 5-HT3[1] |
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| In Vivo | Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors[1]. Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit[2]. |
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| References | [1]. Chetty N, et al. Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract. Pharmacology. 2008;81(2):104-9. Epub 2007 Oct 19. [2]. Coleman NS, et al. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48. |
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Chemical & Physical Properties
| Boiling Point | 529.9ºC at 760mmHg |
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| Molecular Formula | C15H18ClN3O2S |
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| Molecular Weight | 339.840 |
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| Flash Point | 274.3ºC |
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| Exact Mass | 339.080811 |
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| PSA | 96.93000 |
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| LogP | 2.72830 |
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| Vapour Pressure | 2.59E-11mmHg at 25°C |
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| InChIKey | XGVADZZDFADEOO-YDALLXLXSA-N |
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| SMILES | Cl.O=C(NC1CN2CCC1CC2)c1c[nH]c2ccsc2c1=O |
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| Storage condition | 2-8℃ |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride (1:1) |
| Pumosetraghydrochloride |
| (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-7-oxo-4,7-dihydrothieno-[3,2-b]pyridine-6-carboxamide hydrochloride |
| UNII-UVW44TKU66 |
| (R)-N-(3-Quinuclidinyl)-7-oxo-dihydrothieno(3,2b)pyridine-6-carboxamide hydrochloride |
| (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride |
| Thieno[3,2-b]pyridine-6-carboxamide, N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4,7-dihydro-7-oxo-, hydrochloride (1:1) |
| DPP 733 |
| (R)-N-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxothieno[3,2-b]pyridine-6-carboxamide monohydrochloride |
| (R)-N-(3-quinuclidinyl)-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride |
| Pumosetrag Hydrochloride |
