Introduction：Basic information about CAS 518044-40-1|Maleimido-tri(ethylene glycol)-propionic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Maleimido-tri(ethylene glycol)-propionic acid |
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| CAS Number | 518044-40-1 | Molecular Weight | 301.293 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 634.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C13H19NO7 | Melting Point | / |
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| MSDS | / | Flash Point | 337.3±31.5 °C |
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Names
| Name | 3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
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| Target | Cleavable |
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| In Vitro | Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7[1]. ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively[1]. ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 195 and 202 nM, respectively[1]. ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 286 and 274 nM, respectively[1]. |
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| References | [1]. Zhou D,et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 634.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C13H19NO7 |
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| Molecular Weight | 301.293 |
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| Flash Point | 337.3±31.5 °C |
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| Exact Mass | 301.116150 |
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| PSA | 135.37000 |
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| LogP | -1.29 |
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| Vapour Pressure | 0.0±4.2 mmHg at 25°C |
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| Index of Refraction | 1.597 |
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| InChIKey | YSFOTVPQFVYTQX-UHFFFAOYSA-N |
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| SMILES | O=C(O)CCOCCOCCOCCN1C(=O)C=CC1=O |
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Synonyms
| Maleimido-Tri(EthyleneGlycol)-PropionicAcid |
| 1H-Pyrrole-1-propanoic acid, 2,5-dihydro-α,α,β-tris(2-hydroxyethyl)-2,5-dioxo- |
| 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid |
| 3-(2-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)ethoxy)propanoic acid |
| MAL-PEG3-COOH |
