CAS 518-18-3|(+/-)-Evodiamine

Introduction：Basic information about CAS 518-18-3|(+/-)-Evodiamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name(+/-)-Evodiamine
CAS Number518-18-3Molecular Weight303.358
Density1.4±0.1 g/cm3Boiling Point575.1±50.0 °C at 760 mmHg
Molecular FormulaC19H17N3OMelting Point272 °C
MSDS/Flash Point301.6±30.1 °C

Names

Name1-Amino-2-bromo-4-{[3-(dimethylamino)propyl]amino}-9,10-anthraqui none
SynonymMore Synonyms

(+/-)-Evodiamine BiologicalActivity

Description(±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their apoptosis[1].
Related CatalogSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Cell Cycle/DNA Damage >>TopoisomeraseResearch Areas >>Inflammation/Immunology
Target

Top1

References

[1]. Dong G, et, al. New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations. J Med Chem. 2012 Sep 13;55(17):7593-613.

Chemical & Physical Properties

Density1.4±0.1 g/cm3
Boiling Point575.1±50.0 °C at 760 mmHg
Melting Point272 °C
Molecular FormulaC19H17N3O
Molecular Weight303.358
Flash Point301.6±30.1 °C
Exact Mass303.137177
PSA75.43000
LogP1.64
Vapour Pressure0.0±1.6 mmHg at 25°C
Index of Refraction1.764

Safety Information

HS Code2933990090

Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

EVODIAMINE PLANT EXTRACT
8,13,13b,14-Tetrahydro-14-methylindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Indolo(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-
Indol(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bS)-
d-Evodiamine
Evodiamine
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bS)-
)-Evodiamine
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-
14-Methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Evodia rutaecarpa E.P.
Indol(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (S)-
(13bS)-14-Methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
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