CAS 300851-67-6|4-CMTB
Introduction：Basic information about CAS 300851-67-6|4-CMTB, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-CMTB | ||
|---|---|---|---|
| CAS Number | 300851-67-6 | Molecular Weight | 294.80000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H15ClN2OS | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-(4-Chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide |
|---|
4-CMTB BiologicalActivity
| Description | 4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38)[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | 4-CMTB is both a direct agonist and a positive allosteric modulator of the action of short-chain free fatty acids. 4-CMTB modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2)[1][2]. |
| References | [1]. Smith NJ, et al. Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol. 2011;80(1):163-173. [2]. Milligan G, Stoddart LA, Smith NJ. Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br J Pharmacol. 2009;158(1):146-153. |
Chemical & Physical Properties
| Molecular Formula | C14H15ClN2OS |
|---|---|
| Molecular Weight | 294.80000 |
| Exact Mass | 294.05900 |
| PSA | 73.72000 |
| LogP | 4.82430 |
| InChIKey | AZYDQCGCBQYFSE-UHFFFAOYSA-N |
| SMILES | CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1 |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
