CAS 1114544-31-8|Ponatinib hydrochloride
Introduction：Basic information about CAS 1114544-31-8|Ponatinib hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ponatinib hydrochloride | ||
|---|---|---|---|
| CAS Number | 1114544-31-8 | Molecular Weight | 569.02 |
| Density | / | Boiling Point | / |
| Molecular Formula | C29H28ClF3N6O | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide,hydrochloride |
|---|---|
| Synonym | More Synonyms |
Ponatinib hydrochloride BiologicalActivity
| Description | Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>PDGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>SrcSignaling Pathways >>Protein Tyrosine Kinase/RTK >>Bcr-AblSignaling Pathways >>Protein Tyrosine Kinase/RTK >>FGFRSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
| Target | VEGFR2:1.5 nM (IC50) FGFR1:2.2 nM (IC50) PDGFRα:1.1 nM (IC50) Abl:0.37 nM (IC50) LYN:0.24 nM (IC50) Src:5.4 nM (IC50) |
| References | [1]. O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16(5), 401-412. |
Chemical & Physical Properties
| Molecular Formula | C29H28ClF3N6O |
|---|---|
| Molecular Weight | 569.02 |
| Exact Mass | 568.196533 |
| PSA | 65.77000 |
| LogP | 5.20680 |
| InChIKey | BWTNNZPNKQIADY-UHFFFAOYSA-N |
| SMILES | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12.Cl |
Safety Information
| Hazard Codes | Xn |
|---|
Synonyms
| 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}benzamide hydrochloride (1:1) |
| Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-, hydrochloride (1:1) |
| Iclusig (TN) |
| UNII-96R6PU3D8J |
| Ponatinib hydrochloride (USAN) |
| AP 24534 hydrochloride |
| Ponatinib hydrochloride |
| 96R6PU3D8J |
| Ponatinib HCl |
