CAS 1217459-13-6|3,3'-Diiodo-L-thyronine-13C6
| Common Name | 3,3'-Diiodo-L-thyronine-13C6 | ||
|---|---|---|---|
| CAS Number | 1217459-13-6 | Molecular Weight | 531.03300 |
| Density | / | Boiling Point | / |
| Molecular Formula | C15H13I2NO4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid |
|---|---|
| Synonym | More Synonyms |
3,3'-Diiodo-L-thyronine-13C6 BiologicalActivity
| Description | 3,3'-Diiodo-L-thyronine-13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine[1]. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>COXResearch Areas >>Metabolic Disease |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88. [3]. Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb99(1):89-94. [4]. Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun32(6):e4185. |
Chemical & Physical Properties
| Molecular Formula | C15H13I2NO4 |
|---|---|
| Molecular Weight | 531.03300 |
| Exact Mass | 530.91400 |
| PSA | 92.78000 |
| LogP | 4.04840 |
| InChIKey | CPCJBZABTUOGNM-USQDWSSZSA-N |
| SMILES | NC(Cc1ccc(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| RIDADR | NONH for all modes of transport |
Synonyms
| 3,3 inverted exclamation marka-Diiodo-L-thyronine-(phenoxy-13C6) (T2) |
| T2-13C6 |
