Introduction：Basic information about CAS 193681-12-8|alamifovir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | alamifovir |
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| CAS Number | 193681-12-8 | Molecular Weight | 575.42200 |
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| Density | 1.61g/cm3 | Boiling Point | 635.9ºC at 760mmHg |
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| Molecular Formula | C19H20F6N5O5PS | Melting Point | / |
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| MSDS | / | Flash Point | 338.4ºC |
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Names
| Name | alamifovir |
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| Synonym | More Synonyms |
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alamifovir BiologicalActivity
| Description | Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>HBV |
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| In Vitro | MCC-478 (0-10 μM) 对野生型 HBV 的 EC50 为 0.027 μM，对 M552I 为 2.6 μM，对 M552V 为 3.3 μM，对 L528M/M552V 为 2.0 μM[ 1]。 |
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| References | [1]. Suzane Kioko Ono-Nita, et al. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002 Aug;46(8):2602-5. [2]. Danny K W Soon, et al. Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection. J Hepatol. 2004 Nov;41(5):852-8. |
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Chemical & Physical Properties
| Density | 1.61g/cm3 |
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| Boiling Point | 635.9ºC at 760mmHg |
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| Molecular Formula | C19H20F6N5O5PS |
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| Molecular Weight | 575.42200 |
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| Flash Point | 338.4ºC |
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| Exact Mass | 575.08300 |
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| PSA | 158.72000 |
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| LogP | 5.47450 |
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| Vapour Pressure | 4.51E-16mmHg at 25°C |
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| Index of Refraction | 1.582 |
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| InChIKey | VDBGPMJFHCJMOL-UHFFFAOYSA-N |
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| SMILES | COc1ccc(Sc2nc(N)nc3c2ncn3CCOCP(=O)(OCC(F)(F)F)OCC(F)(F)F)cc1 |
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Synonyms
