Introduction：Basic information about CAS 147084-10-4|Alcaftadine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alcaftadine |
|---|
| CAS Number | 147084-10-4 | Molecular Weight | 307.389 |
|---|
| Density | 1.2±0.1 g/cm3 | Boiling Point | 556.2±60.0 °C at 760 mmHg |
|---|
| Molecular Formula | C19H21N3O | Melting Point | 167 °C |
|---|
| MSDS | / | Flash Point | 290.2±32.9 °C |
|---|
Names
| Name | alcaftadine |
|---|
| Synonym | More Synonyms |
|---|
Alcaftadine BiologicalActivity
| Description | Alcaftadine(R89674) is a H1 histamine receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis.Target: H1 Histamine ReceptorAlcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. alcaftadine was more effective than placebo and at least as effective as olopatadine 0.01% in preventing ocular itching at 15 minutes and at 16 hours after administration. Alcaftadine 0.025% ophthalmic solution has been approved by the U.S. Food and Drug Administration for prevention of itching associated with allergic conjunctivitis in patients over 2 years of age [1]. Alcaftadine is a safe and effective option for the prevention of ocular itching associated with allergic conjunctivitis, is dosed once daily, and is competitively priced among prescription medications for allergic conjunctivitis [2]. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Histamine ReceptorSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/Immunology |
|---|
| References | [1]. Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47(12): p. 883-90. [2]. Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46(7-8): p. 1025-32. |
|---|
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|
| Boiling Point | 556.2±60.0 °C at 760 mmHg |
|---|
| Melting Point | 167 °C |
|---|
| Molecular Formula | C19H21N3O |
|---|
| Molecular Weight | 307.389 |
|---|
| Flash Point | 290.2±32.9 °C |
|---|
| Exact Mass | 307.168457 |
|---|
| PSA | 38.13000 |
|---|
| LogP | 3.20 |
|---|
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
|---|
| Index of Refraction | 1.663 |
|---|
| InChIKey | MWTBKTRZPHJQLH-UHFFFAOYSA-N |
|---|
| SMILES | CN1CCC(=C2c3ccccc3CCn3c(C=O)cnc32)CC1 |
|---|
Synonyms
| Lastacaft |
| 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde |
| alcaftadina |
| alcaftadinum |
| 11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine-3-carbaldehyde |
| UNII-7Z8O94ECSX |
| 5H-Imidazo[2,1-b][3]benzazepine-3-carboxaldehyde, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)- |
| Vilasta |
| Alcaftadine |
