Introduction：Basic information about CAS 869884-78-6|Radezolid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Radezolid |
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| CAS Number | 869884-78-6 | Molecular Weight | 438.455 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 712.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H23FN6O3 | Melting Point | / |
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| MSDS | / | Flash Point | 384.7±32.9 °C |
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Names
| Name | N-[[(5S)-3-[3-fluoro-4-[4-[(2H-triazol-4-ylmethylamino)methyl]phenyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide |
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| Synonym | More Synonyms |
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Radezolid BiologicalActivity
| Description | Radezolid is a novel oxazolidinone antibiotic agent. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
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| In Vitro | Radezolid MICs are systematically equal to or lower (up to 3 log2 dilutions) than those of linezolid for all linezolid-susceptible strains, with an 8-fold difference for the linezolid-resistant strains. Radezolid shows a greater potency than linezolid, independent of the bacteria tested, when concentrations are expressed on a weight (mg/L) basis. Radezolid shows an improved potency compared to that of linezolid when concentrations are expressed on a weight (mg/L) basis[1]. Radezolid and TR-700 perform well against 3-copy G2447T, G2576T, and G2576T/T2571C mutants[2]. |
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| Cell Assay | Antibiotic accumulation is determined following the general procedure, and the cellular content of [14C]radezolid is assayed in cell lysates by liquid scintillation counting (lowest limit of detection, 0.003 mg/liter; linear response between 0.01 and 0.78 mg/liter; R2=0.999). All cell drug contents are expressed by reference to the total cell protein content and converted into apparent total cell concentrations using a conversion factor of 5 μL per mg of cell protein. |
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| References | [1]. Lemaire S, et al. Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. [2]. Locke JB, et al. Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations. Antimicrob Agents Chemother. 2010 Dec;54(12):5337-43. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 712.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H23FN6O3 |
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| Molecular Weight | 438.455 |
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| Flash Point | 384.7±32.9 °C |
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| Exact Mass | 438.181580 |
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| PSA | 112.24000 |
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| LogP | 2.28 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.612 |
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| InChIKey | BTTNOGHPGJANSW-IBGZPJMESA-N |
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| SMILES | CC(=O)NCC1CN(c2ccc(-c3ccc(CNCc4cn[nH]n4)cc3)c(F)c2)C(=O)O1 |
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Synonyms
| RX-1741 |
| N-{[(5S)-3-(2-Fluoro-4'-{[(1H-1,2,3-triazol-4-ylmethyl)amino]methyl}-4-biphenylyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide |
| Radezolid |
| UNII-53PC6LO35W |
| RX-103 |
| Acetamide, N-[[(5S)-3-[2-fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]- |
