Introduction：Basic information about CAS 59979-01-0|Thiocillin I, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Thiocillin I |
|---|
| CAS Number | 59979-01-0 | Molecular Weight | 1160.37000 |
|---|
| Density | 1.456g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C48H49N13O10S6 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Thiocillin I |
|---|
| Synonym | More Synonyms |
|---|
Thiocillin I BiologicalActivity
| Description | Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively[1]. |
|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
|---|
| Target | Bacterial[1] |
|---|
| In Vitro | Thiocillin I (2 μM; 24 hours; U-2OS C3 osteosarcoma cells) is not proteasome inhibitor, and does not stabilize expression of multiple cellular proteins and suppresses FoxM1 expression in U-2OS C3 osteosarcoma cells[2]. |
|---|
| References | [1]. Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst. Chem Sci. 2018 Dec 3;10(7):1971-1975. [2]. Pandit B, et al. Proteasome inhibitory activity of thiazole antibiotics. Cancer Biol Ther. 2011 Jan 1;11(1):43-7. |
|---|
Chemical & Physical Properties
| Density | 1.456g/cm3 |
|---|
| Molecular Formula | C48H49N13O10S6 |
|---|
| Molecular Weight | 1160.37000 |
|---|
| Exact Mass | 1159.20000 |
|---|
| PSA | 536.13000 |
|---|
| LogP | 6.40510 |
|---|
| Index of Refraction | 1.659 |
|---|
| InChIKey | FEORQDDAQBRWPT-UHFFFAOYSA-N |
|---|
| SMILES | CC=C(NC(=O)c1csc(-c2csc(-c3ccc4c(n3)-c3csc(n3)C(C(C)O)NC(=O)c3csc(n3)C(C(C)(C)O)NC(=O)c3csc(n3)C(=CC)NC(=O)C(C(C)O)NC(=O)c3csc-4n3)n2)n1)C(=O)NCC(C)O |
|---|
Synonyms
