CAS 956025-83-5|3MB-PP1
Introduction：Basic information about CAS 956025-83-5|3MB-PP1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3MB-PP1 | ||
|---|---|---|---|
| CAS Number | 956025-83-5 | Molecular Weight | 295.38200 |
| Density | 1.209g/cm3 | Boiling Point | 475.471ºC at 760 mmHg |
| Molecular Formula | C17H21N5 | Melting Point | 136-138ºC |
| MSDS | / | Flash Point | 241.356ºC |
Names
| Name | 1-tert-butyl-3-[(3-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine |
|---|---|
| Synonym | More Synonyms |
3MB-PP1 BiologicalActivity
| Description | 3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Apoptosis >>DAPKSignaling Pathways >>Cell Cycle/DNA Damage >>Polo-like Kinase (PLK)Signaling Pathways >>Cell Cycle/DNA Damage >>CDK |
| Target | Leu93-ZIPK:2 μM (IC50) |
| In Vitro | 3MB-PP1 (5 μM; 3 hours) stimulates hyphal growth in a strain bearing analog-sensitive alleles of SSN3[1]. |
| References | [1]. Burkard ME, et al. Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chem Biol. 2012 Jun 15;7(6):978-81. [2]. Hollomon JM, et al. The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway. PLoS Genet. 2022;18(1):e1009622. Published 2022 Jan 4. [3]. Al-Ghabkari A, et al. Validation of chemical genetics for the study of zipper-interacting protein kinase signaling. Proteins. 2018 Nov;86(11):1211-1217. |
Chemical & Physical Properties
| Density | 1.209g/cm3 |
|---|---|
| Boiling Point | 475.471ºC at 760 mmHg |
| Melting Point | 136-138ºC |
| Molecular Formula | C17H21N5 |
| Molecular Weight | 295.38200 |
| Flash Point | 241.356ºC |
| Exact Mass | 295.18000 |
| PSA | 69.62000 |
| LogP | 3.64390 |
| Index of Refraction | 1.64 |
| InChIKey | FYCOTGCSHZKHPR-UHFFFAOYSA-N |
| SMILES | Cc1cccc(Cc2nn(C(C)(C)C)c3ncnc(N)c23)c1 |
Synonyms
| 2wei |
| VGG |
