CAS 737-31-5|Sodium diatrizoate
Introduction：Basic information about CAS 737-31-5|Sodium diatrizoate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sodium diatrizoate | ||
|---|---|---|---|
| CAS Number | 737-31-5 | Molecular Weight | 635.895 |
| Density | / | Boiling Point | 614.1ºC at 760 mmHg |
| Molecular Formula | C11H8I3N2NaO4 | Melting Point | / |
| MSDS | Chinese | Flash Point | 325.2ºC |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | sodium amidotrizoate |
|---|---|
| Synonym | More Synonyms |
Sodium diatrizoate BiologicalActivity
| Description | Sodium diatrizoate is an iodinated radiocontrast agent. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| In Vivo | Sodium diatrizoate is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Sodium diatrizoate nanoparticle agglomerates. Sodium diatrizoate nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1]. |
| Animal Admin | Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Sodium diatrizoate nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1]. |
| References | [1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12. |
Chemical & Physical Properties
| Boiling Point | 614.1ºC at 760 mmHg |
|---|---|
| Molecular Formula | C11H8I3N2NaO4 |
| Molecular Weight | 635.895 |
| Flash Point | 325.2ºC |
| Exact Mass | 635.751587 |
| PSA | 98.33000 |
| LogP | 1.92670 |
| InChIKey | ZEYOIOAKZLALAP-UHFFFAOYSA-M |
| SMILES | CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(=O)[O-])c1I.[Na+] |
| Water Solubility | H2O: 0.35 g/mL, slightly turbid, colorless |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >7 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >7 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20349 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 13200 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 11300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 12200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 2000 ppm
- REFERENCE :
- RADLAX Radiology. (Radiological Soc. of North America, 20th & Northampton Sts., Easton, PA 18042) V.1- 1923- Volume(issue)/page/year: 129,199,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0840 No. of Facilities: 305 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2285 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0840 No. of Facilities: 941 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 22494 (estimated) No. of Female Employees: 15852 (estimated)
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 2000 ppm
- REFERENCE :
- RADLAX Radiology. (Radiological Soc. of North America, 20th & Northampton Sts., Easton, PA 18042) V.1- 1923- Volume(issue)/page/year: 129,199,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0840 No. of Facilities: 305 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2285 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0840 No. of Facilities: 941 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 22494 (estimated) No. of Female Employees: 15852 (estimated)
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H334 |
| Precautionary Statements | P261-P280-P284-P304 + P340-P342 + P311 |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R42/43 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DG6125000 |
| HS Code | 2924299090 |
Customs
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Synonyms
| Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, sodium salt |
| Sodium 3,5-diacetamido-2,4,6-triiodobenzoate |
| EINECS 212-004-1 |
| win8308-3 |
| MFCD00051544 |
| 3,5-Bis(acetylamino)-2,4,6-triiodobenzoic Acid Sodium Salt |
| Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, monosodium salt |
| Diatrizoate sodium salt |
| HYPAQUE SODIUM |
| 3,5-diacetamido-2,4,6-triiodobenzoic acid sodium salt |
| gastrografin |
| histopaque |
| sodium 3,5-bis(acetylamino)-2,4,6-triiodobenzoate |
| hypaque |
| diatrizoate |
| Amidotrizoate Sodium |
| Radioselectan |
| triombrine |
| hypaque50 |
| diatrizoic acid sodium salt |
| Sodium diatrizoate |
| Conray 35 |
| 3,5-bis-acetylamino-2,4,6-triiodo-benzoic acid,sodium-salt |
| sodium amidotrizoate |
| Urografic Acid Sodium Salt |
| Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, sodium salt (1:1) |
| Diatrizoate Sodium |
