CAS 110862-48-1|(rel)-Atorvastatin

Introduction：Basic information about CAS 110862-48-1|(rel)-Atorvastatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (rel)-Atorvastatin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	(rel)-Atorvastatin
CAS Number	110862-48-1	Molecular Weight	558.640
Density	1.2±0.1 g/cm3	Boiling Point	722.2±60.0 °C at 760 mmHg
Molecular Formula	C₃₃H₃₅FN₂O₅	Melting Point	/
MSDS	/	Flash Point	390.6±32.9 °C

Names

Name	Atorvastatin
Synonym	More Synonyms

(rel)-Atorvastatin BiologicalActivity

Description	(rel)-Atorvastatin, a relative configuration of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease
References	[1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [4]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.

Description

(rel)-Atorvastatin, a relative configuration of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease

References

[1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22.

[2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.

[3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.

[4]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	722.2±60.0 °C at 760 mmHg
Molecular Formula	C₃₃H₃₅FN₂O₅
Molecular Weight	558.640
Flash Point	390.6±32.9 °C
Exact Mass	558.252991
PSA	111.79000
LogP	4.13
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.603
InChIKey	XUKUURHRXDUEBC-UHFFFAOYSA-N
SMILES	CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CCC(O)CC(O)CC(=O)O

Safety Information

HS Code	2942000000

Customs

HS Code	2942000000

Synonyms

1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βS,δS)-

(3S,5S)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid

UNII:36TN91XZ0V

1h-pyrrole-1-heptanoic acid

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