CAS 4345-03-3|VES
Introduction：Basic information about CAS 4345-03-3|VES, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | VES | ||
|---|---|---|---|
| CAS Number | 4345-03-3 | Molecular Weight | 530.779 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 625.8±55.0 °C at 760 mmHg |
| Molecular Formula | C33H54O5 | Melting Point | ~76 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 187.0±25.0 °C |
Names
| Name | α-Tocopheryl Succinate |
|---|---|
| Synonym | More Synonyms |
VES BiologicalActivity
| Description | D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
| In Vitro | D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1]. D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1]. D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2]. Cell Cytotoxicity Assay[1] Cell Line: HEI-OC1 cell line Concentration: 1-20 μM Incubation Time: 24 hours Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM. Cell Viability Assay[1] Cell Line: HEI-OC1 cell line Concentration: 10 μM Incubation Time: 48 hours Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis. Cell Cytotoxicity Assay[2] Cell Line: TC-1 tumor cells Concentration: 0, 25 and 50 μM Incubation Time: 18 hours Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells. |
| In Vivo | D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor[2]. Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2] Dosage: 1 and 2 mg/kg Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days Result: Dreased the tumor volume, especially with a dose of 2 mg/kg. |
| References | [1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14. [2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 625.8±55.0 °C at 760 mmHg |
| Melting Point | ~76 °C(lit.) |
| Molecular Formula | C33H54O5 |
| Molecular Weight | 530.779 |
| Flash Point | 187.0±25.0 °C |
| Exact Mass | 530.397095 |
| PSA | 72.83000 |
| LogP | 11.88 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.498 |
| InChIKey | IELOKBJPULMYRW-NJQVLOCASA-N |
| SMILES | Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)O)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2 |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 25,273,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1129 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | EJ9984000 |
Articles14
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Synonyms
| a-Tocopheryl Succinate |
| Butanedioic Acid (2R-(2R*(4R*,8R*)))-mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester |
| a-Tocopheryl Acid Succinate |
| α-Tocopheryl acid succinate |
| (+)-α-Tocopheryl succinate |
| VES |
| EINECS 224-403-8 |
| D-α-Tocopherol succinate |
| (+)-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl Hydrogen Succinate |
| a-Tocopherol Acid Succinate |
| mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) butanedioate |
| Butanedioic acid Mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester |
| d-alpha-Tocopherol succinate(E) |
| a-Tocopheryl Hydrogen Succinate |
| Butanedioic acid, mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester |
| 4-Oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl}oxy)butanoic acid |
| a-Tocopherol Hemisuccinate |
| Vitamin E Succinate |
| MFCD00072055 |
| Covitol 1210 |
| (+)-a-Tocopheryl Succinate |
