CAS 119478-55-6|Danofloxacin Mesylate

Introduction：Basic information about CAS 119478-55-6|Danofloxacin Mesylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Danofloxacin Mesylate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Danofloxacin Mesylate
CAS Number	119478-55-6	Molecular Weight	453.484
Density	/	Boiling Point	569.3ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄FN₃O₆S	Melting Point	337-339ºC
MSDS	/	Flash Point	298.1ºC

Names

Name	Danofloxacin Mesylate
Synonym	More Synonyms

Danofloxacin Mesylate BiologicalActivity

Description	Danofloxacin Mesylate(CP76136-27 mesylate) is a fluoroquinolone antibacterial for veterinary use.Target: AntibacterialDanofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml [1]. Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay [2].
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialNatural Products >>AlkaloidResearch Areas >>Infection
References	[1]. Giles, C.J., et al., Clinical pharmacokinetics of parenterally administered danofloxacin in cattle. J Vet Pharmacol Ther, 1991. 14(4): p. 400-10. [2]. McGuirk, P.R., et al., Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. J Med Chem, 1992. 35(4): p. 611-20.

Description

Danofloxacin Mesylate(CP76136-27 mesylate) is a fluoroquinolone antibacterial for veterinary use.Target: AntibacterialDanofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml [1]. Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay [2].

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialNatural Products >>AlkaloidResearch Areas >>Infection

References

[1]. Giles, C.J., et al., Clinical pharmacokinetics of parenterally administered danofloxacin in cattle. J Vet Pharmacol Ther, 1991. 14(4): p. 400-10.

[2]. McGuirk, P.R., et al., Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. J Med Chem, 1992. 35(4): p. 611-20.

Chemical & Physical Properties

Boiling Point	569.3ºC at 760 mmHg
Melting Point	337-339ºC
Molecular Formula	C₂₀H₂₄FN₃O₆S
Molecular Weight	453.484
Flash Point	298.1ºC
Exact Mass	453.136993
PSA	128.53000
LogP	2.65410
Vapour Pressure	8.41E-14mmHg at 25°C
InChIKey	APFDJSVKQNSTKF-FXMYHANSSA-N
SMILES	CN1CC2CC1CN2c1cc2c(cc1F)c(=O)c(C(=O)O)cn2C1CC1.CS(=O)(=O)O
Storage condition	0-6°C

Safety Information

Hazard Codes	T+
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

CP 76136-27

Danofioxacin Mesylate

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-, methanesulfonate (1:1)

MFCD00673687

1-Cyclopropyl-6-fluoro-1,4-dihydro-7-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-4-oxo-3-quinolinecarboxylic Acid Monomethanesulfonate

1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methanesulfonate (1:1)

1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate (1:1)

Danofloxacin mesylate

Danofloxacin (mesylate)

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