Introduction：Basic information about CAS 43210-67-9|fenbendazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | fenbendazole |
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| CAS Number | 43210-67-9 | Molecular Weight | 299.348 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 541.4±42.0 °C at 760 mmHg |
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| Molecular Formula | C15H13N3O2S | Melting Point | 233°C |
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| MSDS | ChineseUSA | Flash Point | 281.2±27.9 °C |
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Names
| Name | fenbendazole |
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| Synonym | More Synonyms |
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fenbendazole BiologicalActivity
| Description | Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites.Target: AntiparasiticFenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the taenia species of tapeworms(It is effective against the Taenia species of tapeworm but not against the common tapeworm, Dipylidium caninum.), pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together. Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally. From Wikipedia. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
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| References | [1]. http://en.wikipedia.org/wiki/Fenbendazole |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 541.4±42.0 °C at 760 mmHg |
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| Melting Point | 233°C |
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| Molecular Formula | C15H13N3O2S |
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| Molecular Weight | 299.348 |
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| Flash Point | 281.2±27.9 °C |
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| Exact Mass | 299.072845 |
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| PSA | 92.31000 |
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| LogP | 4.34 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.679 |
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| InChIKey | HDDSHPAODJUKPD-UHFFFAOYSA-N |
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| SMILES | COC(=O)Nc1nc2ccc(Sc3ccccc3)cc2[nH]1 |
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| Storage condition | 0-6°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DD6520500
- CHEMICAL NAME :
- 2-Benzimidazolecarbamic acid, 5-(phenylthio)-, methyl ester
- CAS REGISTRY NUMBER :
- 43210-67-9
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C15-H13-N3-O2-S
- MOLECULAR WEIGHT :
- 299.37
- WISWESSER LINE NOTATION :
- T56 BM DNJ CMVO1 GSR
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - pig
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - domestic
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 gm/kg/14D-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 2 mg/L
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26-36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 2 |
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| RTECS | DD6520500 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles4
More Articles
| Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014) A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be... | |
| Epidemiology. Opposite effects of anthelmintic treatment on microbial infection at individual versus population scales. Science 347(6218) , 175-7, (2015) Parasitic worms modulate host immune responses in ways that affect microbial co-infections. For this reason, anthelmintic therapy may be a potent tool for indirectly controlling microbial pathogens. H... | |
| Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: pharmacological implications. Vet. J. 181(3) , 241-50, (2009) Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to alben... | |
Synonyms
| Fenbendazole |
| HOE-881V |
| Methyl [5-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbamate |
| Methyl hydrogen [6-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbonimidate |
| SAFEGARD |
| MFCD00144301 |
| 5-(Phenylthio)-2-benzimidazolecarbamic Acid Methyl Ester |
| hoe881 |
| fenbendazol |
| Carbamic acid, N-[6-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester |
| EINECS 256-145-7 |
| Febendazole |
| Fenbedazole |
| [5-(Phenylthio)benzimidazol-2-yl]carbamic Acid Methyl Ester |
| Methanol, 1-methoxy-1-[[6-(phenylthio)-1H-benzimidazol-2-yl]imino]-, (E)- |
| PANACUR |
| Fenbion |
| Methyl 5-(phenylthio)-2-benzimidazolecarbamate |
| Methyl [5-(Phenylthio)benzimidazol-2-yl]carbamate |
