CAS 149022-22-0|Amikacin sulfate

Introduction：Basic information about CAS 149022-22-0|Amikacin sulfate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Amikacin sulfate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles1
7. Synonyms

Common Name	Amikacin sulfate
CAS Number	149022-22-0	Molecular Weight	781.760
Density	/	Boiling Point	981.8ºC at 760mmHg
Molecular Formula	C₂₂H₄₃N₅O_13.9/₅H₂O₄S	Melting Point	/
MSDS	ChineseUSA	Flash Point	547.6°C

Names

Name	Amikacin sulfate salt
Synonym	More Synonyms

Amikacin sulfate BiologicalActivity

Description	Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial
In Vitro	Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi)[1]. Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM[3].
In Vivo	Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3]. Animal Model: Male Fischer 344 rats (40-50-day-old)[3] Dosage: 320 mg/kg Administration: Subcutaneous injection; daily; for 10 days Result: Induced hearing loss in rats.
References	[1]. Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28. [2]. Ristuccia AM, et al. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25. [3]. Siân R Kitcher, et al. ORC-13661 Protects Sensory Hair Cells From Aminoglycoside and Cisplatin Ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764.

Chemical & Physical Properties

Boiling Point	981.8ºC at 760mmHg
Molecular Formula	C₂₂H₄₃N₅O_13.9/₅H₂O₄S
Molecular Weight	781.760
Flash Point	547.6°C
Exact Mass	781.220520
PSA	497.90000
Appearance of Characters	white to off-white
Vapour Pressure	0mmHg at 25°C
InChIKey	HIBICIOPDUTNRR-BOEHXBESSA-N
SMILES	NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC1OC(CO)C(O)C(N)C1O.O=S(=O)(O)O
Storage condition	2-8°C
Water Solubility	H2O: soluble50mg/mL

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	WK1961200
HS Code	2941902000

Customs

HS Code	2941902000

Articles1

High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.

PLoS Pathog. 5(10) , e1000645, (2009)

A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for ...

Synonyms

AMIKACIN SULFATE 1:1.8

Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy-, (2S)-, sulfate (1:2) (s alt)

(2S)-4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (1:2)

amikacin sulphate

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