Introduction：Basic information about CAS 204656-20-2|Liraglutide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Liraglutide |
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| CAS Number | 204656-20-2 | Molecular Weight | 3751.20000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C172H265N43O51 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | liraglutide |
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| Synonym | More Synonyms |
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Liraglutide BiologicalActivity
| Description | Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Glucagon ReceptorResearch Areas >>Metabolic DiseasePeptidesPeptides |
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| Target | GLP-1 receptor[1] |
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| In Vitro | Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1 that stimulates insulin secretion. Liraglutide is an injectable drug for the treatment of type 2 diabetes, also can be used to treat obesity in adults with some related comorbidity. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells[1]. |
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| Cell Assay | Raw264.7 macrophage cells are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO2. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nM) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination[1]. |
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| References | [1]. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9. [2]. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416. |
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Chemical & Physical Properties
| Molecular Formula | C172H265N43O51 |
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| Molecular Weight | 3751.20000 |
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| Exact Mass | 3748.95000 |
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| PSA | 1513.76000 |
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| LogP | 6.12960 |
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| InChIKey | YSDQQAXHVYUZIW-QCIJIYAXSA-N |
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| SMILES | CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)NC(C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)C(C)CC)C(=O)O |
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| Storage condition | -20°C |
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Synonyms
