Introduction：Basic information about CAS 835621-11-9|Regorafenib N-Oxide(M2), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Regorafenib N-Oxide(M2) |
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| CAS Number | 835621-11-9 | Molecular Weight | 498.81500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H15ClF4N4O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | bay 75-7495 |
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| Synonym | More Synonyms |
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Regorafenib N-Oxide(M2) BiologicalActivity
| Description | Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cancer |
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| References | [1]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48. |
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Chemical & Physical Properties
| Molecular Formula | C21H15ClF4N4O4 |
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| Molecular Weight | 498.81500 |
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| Exact Mass | 498.07200 |
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| PSA | 104.92000 |
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| LogP | 6.25920 |
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| InChIKey | NUCXNEKIESREQY-UHFFFAOYSA-N |
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| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)cc[n+]1[O-] |
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Synonyms
| Regorafenib N-oxide (M2 Metabolite) |
| Regorafenib N-Oxide(M2) |
