CAS 38647-11-9|Triptonide

Introduction：Basic information about CAS 38647-11-9|Triptonide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Triptonide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Triptonide
CAS Number	38647-11-9	Molecular Weight	358.385
Density	1.5±0.1 g/cm3	Boiling Point	581.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₂O₆	Melting Point	/
MSDS	ChineseUSA	Flash Point	257.8±30.2 °C
Symbol	GHS06, GHS08	Signal Word	Danger

Names

Name	Triptonide
Synonym	More Synonyms

Triptonide BiologicalActivity

Description	Triptonide(NSC 165677; PG 492), extracted from Tripterygium wilfordii Hook, inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 mg/ml.
Related Catalog	Signaling Pathways >>Stem Cell/Wnt >>β-cateninSignaling Pathways >>Stem Cell/Wnt >>WntResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides
References	[1]. Wu YW, Jiang YY, Xiao TX, Zhang HL.Determination of triptonide by cloud point extraction combined with MEKC.J Sep Sci. 2008 Mar;31(5):865-71. [2]. Yao J, Zhang L, Zhao X, Hu L, Jiang Z.Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.Biol Pharm Bull. 2006 Jul;29(7):1483-6. [3]. Wang Z, Wen J, Xing J, Guo D.Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography.Biomed Chromatogr. 2005 Jan;19(1):60-2. [4]. Wang L, Ye W, Hui L, Liu X, Guo Y.[Male contraception of triptonide and its function mechanism].Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Jun;22(3):223-6. [5]. Corson, Timothy W.; Cavga, Hueseyin; Aberle, Nicholas; Crews, Craig M. Triptolide Directly Inhibits dCTP Pyrophosphatase. ChemBioChem (2011), 12(11), 1767-1773.

Description

Triptonide(NSC 165677; PG 492), extracted from Tripterygium wilfordii Hook, inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 mg/ml.

Related Catalog

Signaling Pathways >>Stem Cell/Wnt >>β-cateninSignaling Pathways >>Stem Cell/Wnt >>WntResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides

References

[1]. Wu YW, Jiang YY, Xiao TX, Zhang HL.Determination of triptonide by cloud point extraction combined with MEKC.J Sep Sci. 2008 Mar;31(5):865-71.

[2]. Yao J, Zhang L, Zhao X, Hu L, Jiang Z.Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.Biol Pharm Bull. 2006 Jul;29(7):1483-6.

[3]. Wang Z, Wen J, Xing J, Guo D.Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography.Biomed Chromatogr. 2005 Jan;19(1):60-2.

[4]. Wang L, Ye W, Hui L, Liu X, Guo Y.[Male contraception of triptonide and its function mechanism].Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Jun;22(3):223-6.

[5]. Corson, Timothy W.; Cavga, Hueseyin; Aberle, Nicholas; Crews, Craig M. Triptolide Directly Inhibits dCTP Pyrophosphatase. ChemBioChem (2011), 12(11), 1767-1773.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	581.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₂O₆
Molecular Weight	358.385
Flash Point	257.8±30.2 °C
Exact Mass	358.141632
PSA	80.96000
LogP	1.49
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.638
InChIKey	SWOVVKGLGOOUKI-ZHGGVEMFSA-N
SMILES	CC(C)C12OC1C1OC13C1(C)CCC4=C(COC4=O)C1CC1OC13C2=O
Storage condition	2-8°C

Safety Information

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300 + H330-H361f
Precautionary Statements	P201-P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
Hazard Codes	T+
RIDADR	2811.0
Hazard Class	6.1

Synonyms

l-triptonide

Triptolide,14-deoxy-14-oxo

Triptonide

(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-Isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione

Trisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione, 3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-

14-Deoxy-14-oxotriptolide

(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-8b-methyl-6a-(propan-2-yl)-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione

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