CAS 121-87-9|2-Chloro-4-nitroaniline

Introduction：Basic information about CAS 121-87-9|2-Chloro-4-nitroaniline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles4
7. Synonyms

Common Name	2-Chloro-4-nitroaniline
CAS Number	121-87-9	Molecular Weight	172.569
Density	1.5±0.1 g/cm3	Boiling Point	326.2±22.0 °C at 760 mmHg
Molecular Formula	C₆H₅ClN₂O₂	Melting Point	107 °C
MSDS	ChineseUSA	Flash Point	151.1±22.3 °C
Symbol	GHS07, GHS09	Signal Word	Warning

Names

Name	2-Chloro-4-nitroaniline
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	326.2±22.0 °C at 760 mmHg
Melting Point	107 °C
Molecular Formula	C₆H₅ClN₂O₂
Molecular Weight	172.569
Flash Point	151.1±22.3 °C
Exact Mass	172.003952
PSA	71.84000
LogP	2.46
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.646
InChIKey	LOCWBQIWHWIRGN-UHFFFAOYSA-N
SMILES	Nc1ccc([N+](=O)[O-])cc1Cl
Stability	Stable. Incompatible with strong oxidizing agents, strong bases, strong acids.
Water Solubility	0.23 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX1400000

CHEMICAL NAME :: Aniline, 2-chloro-4-nitro-

CAS REGISTRY NUMBER :: 121-87-9

BEILSTEIN REFERENCE NO. :: 0638657

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C6-H5-Cl-N2-O2

MOLECULAR WEIGHT :: 172.58

WISWESSER LINE NOTATION :: ZR BG DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 29,34,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0882 No. of Facilities: 708 (estimated) No. of Industries: 12 No. of Occupations: 9 No. of Employees: 2937 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0882 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 737 (estimated)

Safety Information

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H411
Precautionary Statements	P273
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R51/53
Safety Phrases	S22-S24-S61
RIDADR	UN 2237 6.1/PG 3
WGK Germany	2
RTECS	BX1400000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2921420090

Customs

HS Code	2921420090
Summary	HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles4

[Toxicity of 4-chloro-2-nitroaniline and 2-chloro-4-nitroaniline to isolated rat hepatocytes].

Med. Lav. 82(3) , 253-60, (1991)

The toxicity of 4-chloro-2-nitroaniline (4C2NA) and 2-chloro-4-nitroaniline (2C4NA) was investigated on isolated rat hepatocytes following 1-3 hours of exposure to 0.2 and/or 2 mM of these xenobiotics...

Mutagenic activity of 2-chloro-4-nitroaniline and 5-chlorosalicylic acid in Salmonella typhimurium: two possible metabolites of niclosamide.

Mutat. Res. 264(3) , 139-45, (1991)

Niclosamide is an anti-helminthic drug susceptible to being metabolized into a bacterial mutagen by the action of enzymes present in the S9 activation mixture. Additional results from genotoxic studie...

Liquid chromatographic determination of 2-chloro-4-nitroaniline, 2-naphthol, and 2,4-dinitroaniline in D&C red no. 36.

J. AOAC Int. 76(2) , 287-91, (1993)

A method is described for the determination of the intermediates and a related impurity in D&C Red No. 36 by reversed-phase liquid chromatography. This method may be used to ensure that limits set for...

Synonyms

ocpn

2-Chloro-4-nitrobenzenamine

2-chloro-4-nitrophenylamine

1-Amino-2-chloro-4-nitrobenzene

o-chloro-nitroaniline

EINECS 204-502-2

4-NITRO-2-CHLOROANILINE

2-chloro-4-nitro-aniline

MFCD00007665

2-Chlor-4-nitroanilin

ZR BG DNW

2-Chloro-4-nitroaniline

OCPNA

Benzenamine, 2-chloro-4-nitro-

2-/-4-CHLORONITROANILIN

2-chloro-4-nitro-anilin

2-Chloro-4-nitroanil

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