CAS 87-62-7|2,6-xylidine

Introduction：Basic information about CAS 87-62-7|2,6-xylidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles30
7. Synonyms

Common Name	2,6-xylidine
CAS Number	87-62-7	Molecular Weight	121.180
Density	1.0±0.1 g/cm3	Boiling Point	217.9±0.0 °C at 760 mmHg
Molecular Formula	C₈H₁₁N	Melting Point	10-12 °C(lit.)
MSDS	ChineseUSA	Flash Point	91.1±0.0 °C
Symbol	GHS07, GHS08, GHS09	Signal Word	Warning

Names

Name	2,6-dimethylaniline
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	217.9±0.0 °C at 760 mmHg
Melting Point	10-12 °C(lit.)
Molecular Formula	C₈H₁₁N
Molecular Weight	121.180
Flash Point	91.1±0.0 °C
Exact Mass	121.089149
PSA	26.02000
LogP	1.86
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.559
InChIKey	UFFBMTHBGFGIHF-UHFFFAOYSA-N
SMILES	Cc1cccc(C)c1N
Water Solubility	7.5 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE9275000

CHEMICAL NAME :: 2,6-Xylidine

CAS REGISTRY NUMBER :: 87-62-7

BEILSTEIN REFERENCE NO. :: 0636332

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C8-H11-N

MOLECULAR WEIGHT :: 121.20

WISWESSER LINE NOTATION :: ZR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Blood - changes in spleen

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 707 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3150 mg/kg/20D-C

TOXIC EFFECTS :: Blood - changes in spleen

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6200 mg/kg/2W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13300 mg/kg/4W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20150 mg/kg/13W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Endocrine - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 301 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7951 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

Safety Information

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H335-H351-H411
Precautionary Statements	P261-P273-P280
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R20/21/22;R37/38;R40;R51/53
Safety Phrases	S23-S25-S36/37-S61
RIDADR	UN 1711 6.1/PG 2
WGK Germany	2
RTECS	ZE9275000
Packaging Group	II
Hazard Class	6.1
HS Code	29214910

Customs

HS Code	2921430090
Summary	HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles30

Simultaneous Determination of Xylazine and 2,6-Xylidine in Blood and Urine by Auto Solid-Phase Extraction and Ultra High Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry.

J. Anal. Toxicol. 39 , 444-50, (2015)

Xylazine as veterinary medicine for sedation, but intoxication cases in humans were identified in the last few years. A highly sensitive method is required for analyzing xylazine and its metabolites i...

A Novel Method for Assessing Drug Degradation Product Safety Using Physiologically-Based Pharmacokinetic Models and Stochastic Risk Assessment.

J. Pharm. Sci. 104 , 3101-19, (2015)

Patient safety risk due to toxic degradation products is a potentially critical quality issue for a small group of useful drug substances. Although the pharmacokinetics of toxic drug degradation produ...

Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1256-64, (2015)

Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under...

Synonyms

o-Xylidine

2-Amino-1,3-xylene

2,6-dimethyl-aniline

Benzene, 2-amino-1,3-dimethyl-

1-amino-2,6-dimethybenzene

Benzenamine,2,6-dimethyl

2,6-xylidine

2,6-dimethylphenylamine

2,6-dimethylbenzeneamine

aniline, 2,6-dimethyl-

MFCD00007747

2-amino-1,3-dimethylbenzene

Benzenamine, 2,6-dimethyl-

2,6-Dimethylbenzenamine

2,6-Dimethylaniline

2-Amino-m-xylene

2,5-DIMETHOXYTOLUENE

1-amino-2,6-dimethylbenzene

2,6-methylaniline

EINECS 201-758-7

2,6-dimethyl aniline

Bupivacaine Impurity 8

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