Introduction：Basic information about CAS 554-92-7|Trimethobenzamide hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trimethobenzamide hydrochloride |
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| CAS Number | 554-92-7 | Molecular Weight | 424.91800 |
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| Density | 1.131g/cm3 | Boiling Point | 506.9ºC at 760mmHg |
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| Molecular Formula | C21H29ClN2O5 | Melting Point | 187.5-190° |
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| MSDS | / | Flash Point | / |
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| Symbol |
GHS07, GHS08 | Signal Word | Danger |
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Names
| Name | N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide,hydrochloride |
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| Synonym | More Synonyms |
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Trimethobenzamide hydrochloride BiologicalActivity
| Description | Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Others |
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| Target | D2 receptor[1] |
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| In Vitro | Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1]. |
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| In Vivo | The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1]. |
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| References | [1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42. |
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Chemical & Physical Properties
| Density | 1.131g/cm3 |
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| Boiling Point | 506.9ºC at 760mmHg |
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| Melting Point | 187.5-190° |
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| Molecular Formula | C21H29ClN2O5 |
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| Molecular Weight | 424.91800 |
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| Exact Mass | 424.17600 |
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| PSA | 69.26000 |
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| LogP | 3.77570 |
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| InChIKey | WIIZEEPFHXAUND-UHFFFAOYSA-N |
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| SMILES | COc1cc(C(=O)NCc2ccc(OCCN(C)C)cc2)cc(OC)c1OC.Cl |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CV4550000
- CHEMICAL NAME :
- Benzamide, N-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethox y-, hydrochloride
- CAS REGISTRY NUMBER :
- 554-92-7
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C21-H28-N2-O5.Cl-H
- MOLECULAR WEIGHT :
- 424.97
- WISWESSER LINE NOTATION :
- 1OR BO1 CO1 EVM1R DO2N1&1 &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 174,350,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 126,270,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 564 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 174,350,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 122 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 174,350,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4629 No. of Facilities: 109 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 3651 (estimated) No. of Female Employees: 3453 (estimated)
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Safety Information
| Symbol |
GHS07, GHS08 |
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| Signal Word | Danger |
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| Hazard Statements | H302-H317-H334 |
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| Precautionary Statements | P261-P280-P284-P301 + P312 + P330-P304 + P340-P342 + P311 |
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| Risk Phrases | 20/21/22 |
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| Safety Phrases | 36 |
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| RIDADR | UN 2811 6.1/PG 2 |
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| WGK Germany | 3 |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Ametik hydrochloride |
| Trimethobenzamide hydrochloride |
| 3,4,5-trimethoxy-benzoic acid-[4-(2-dimethylamino-ethoxy)-benzylamide],hydrochloride |
| Trimethobenzamide HCL |
| Ibikin |
| UNII-WDQ5P1SX7Q |
| EINECS 209-075-6 |
| Tigan |
| 3,4,5-Trimethoxy-benzoesaeure-[4-(2-dimethylamino-aethoxy)-benzylamid],Hydrochlorid |
| N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide hydrochloride |
| Poligerim |
| Anaus |
| N-[p-[(2-dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide hydrochloride |
| Nauseton |
| trimethoxybenzamide hydrochloride |
| trimethobenzamide chlorohydrate |
