CAS 14038-43-8|Prussian blue

Introduction：Basic information about CAS 14038-43-8|Prussian blue, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Prussian blue BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles38
8. Synonyms

Common Name	Prussian blue
CAS Number	14038-43-8	Molecular Weight	859.228
Density	1.8	Boiling Point	25.7ºC at 760 mmHg
Molecular Formula	C₁₈Fe₇N₁₈	Melting Point	/
MSDS	ChineseUSA	Flash Point	/

Names

Name	ferric ferrocyanide
Synonym	More Synonyms

Prussian blue BiologicalActivity

Description	Prussian blue insoluble (Iron(III) ferrocyanide) is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue insoluble (Iron(III) ferrocyanide) has anticancerous and antibacterial properties. Prussian blue insoluble (Iron(III) ferrocyanide) can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI). Prussian blue insoluble can be used for contrast agents, antidotes and cancer research[1][2][3][4].
Related Catalog	Research Areas >>CancerResearch Areas >>InfectionResearch Areas >>OthersSignaling Pathways >>Anti-infection >>Bacterial
In Vitro	Prussian blue insoluble (Iron(III) ferrocyanide) (0.1-3.0μg/mL; 24 hours; HUVECs) has photo-thermal effect and inhibits cell viabilities[1]. Prussian blue insoluble (Iron(III) ferrocyanide) (0.07 mM; 0-24 hours) act as a metabolic indicator, being reduced by bacterial metabolism, producing a visible color change from blue to colorless[2]. Cell Viability Assay[1] Cell Line: HUVECs Concentration: 24 hours Incubation Time: 0.1, 0.2, 0.5, 1.0, 2.0 and 3.0 μg/mL Result: Decreased the cell viabilities as the time of NIR laser irradiation
In Vivo	Prussian blue insoluble (3 g/day; p.o.; for 8 days; rats)(Iron(III) ferrocyanide) can be used as a therapeutic agent in radiocesium and thallium poisoning[3]. Animal Model: Rats[3] Dosage: 3 g/day Administration: Oral administration; 8 days Result: Increased excretion of cesium-134.
References	[1]. Chen HJ, et, al. Facile synthesis of Prussian blue nanoparticles as pH-responsive drug carriers for combined photothermal-chemo treatment of cancer. RCS advances. 2016 Oct 9; 7:248-255. [2]. Ferrer-Vilanova A, et, al. Electrochromogenic Detection of Live Bacteria Using Soluble and Insoluble Prussian Blue. ACS Omega. 2021 Nov 11;6(46):30989-30997. [3]. Thompson DF, et, al. Soluble or insoluble prussian blue for radiocesium and thallium poisoning? Ann Pharmacother. 2004 Sep;38(9):1509-14. [4]. Busquets MA, et, al. Prussian blue nanoparticles: synthesis, surface modification, and biomedical applications. Drug Discov Today. 2020 Aug;25(8):1431-1443.

Chemical & Physical Properties

Density	1.8
Boiling Point	25.7ºC at 760 mmHg
Molecular Formula	C₁₈Fe₇N₁₈
Molecular Weight	859.228
Exact Mass	859.599915
PSA	428.22000
LogP	0.28454
Vapour Pressure	740mmHg at 25°C
Stability	Stable. Incompatible with strong acids, strong oxidizing agents, ammonia. Light sensitive.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LJ8200000

CAS REGISTRY NUMBER :: 14038-43-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C18-Fe3-N18.4Fe

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 35(1),35,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Liver - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 35(1),35,1991

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 35(1),35,1991

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 35(1),35,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Blood - changes in spleen

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 35(1),35,1991

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 35(1),35,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1624 No. of Facilities: 5778 (estimated) No. of Industries: 67 No. of Occupations: 58 No. of Employees: 85363 (estimated) No. of Female Employees: 20494 (estimated)

Safety Information

Hazard Codes	Xn,T,F,Xi
Risk Phrases	R40:Limited evidence of a carcinogenic effect. R22:Harmful if swallowed. R10:Flammable. R36/38:Irritating to eyes and skin . R23/25:Toxic by inhalation and if swallowed . R11:Highly Flammable. R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	22-24/25
RIDADR	UN 1993
WGK Germany	1
RTECS	LJ8200000
HS Code	29322910

Customs

HS Code	29322910

Articles38

Visible spectrophotometric method for amiodarone.

Rev. Med. Chir. Soc. Med. Nat. Iasi. 116(1) , 330-5, (2012)

Amiodarone is an antiarrhythmic agent used for various types of tachyarrhythmia, both ventricular and supraventricular (atrial) arrhythmia. A spectrophotometric method for the assay of amiodarone was ...

Prussian blue modified ferritin as peroxidase mimetics and its applications in biological detection.

J. Nanosci. Nanotechnol. 13(1) , 60-7, (2013)

Ferritins are natural nanoscale structures composed with 24 subunits endowed with similar three-dimensional structures. The iron is stored in the form of ferrihydrite phosphate in the hollow spherical...

A branched electrode based electrochemical platform: towards new label-free and reagentless simultaneous detection of two biomarkers.

Chem. Commun. (Camb.) 49(11) , 1052-4, (2013)

A branched electrode platform was proposed for label-free and reagentless simultaneous tumor markers detection based on different redox substrates.

Synonyms

Iron(3+) hexakis(cyano-κC)ferrate(4-) (4:3)

Tetrairon(3+) tris[hexacyanoferrate(4-)]

PARIS BLUE

EINECS 237-875-5

BERLIN BLUE

Miroli Blue

Ferrate(4-), hexakis(cyano-κC)-, iron(3+) (3:4)

Prussian blue

MFCD00135663

Iron(III) Hexacyanoferrate(II)

CHINESE BLUE

Iron(III) Ferrocyanide

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