Introduction：Basic information about CAS 219138-02-0|Z-Ile-Glu-Thr-Asp-AFC, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Z-Ile-Glu-Thr-Asp-AFC |
|---|
| CAS Number | 219138-02-0 | Molecular Weight | 821.75000 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C37H42F3N5O13 | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | / |
|---|
Names
| Name | Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin |
|---|
| Synonym | More Synonyms |
|---|
Z-Ile-Glu-Thr-Asp-AFC BiologicalActivity
| Description | Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
|---|
| References | [1]. Boudard D, et al. Increased caspase-3 activity in refractory anemias: lack of evidence for Fas pathway implication. Leukemia. 2002;16(11):2343-2345. |
|---|
Chemical & Physical Properties
| Molecular Formula | C37H42F3N5O13 |
|---|
| Molecular Weight | 821.75000 |
|---|
| Exact Mass | 821.27300 |
|---|
| PSA | 279.77000 |
|---|
| LogP | 3.90270 |
|---|
| InChIKey | RCIFCAJYIPUCJW-QXPVPWKFSA-N |
|---|
| SMILES | CCC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(=O)O)C(=O)Nc1ccc2c(C(F)(F)F)cc(=O)oc2c1)C(C)O |
|---|
| Storage condition | −20°C |
|---|
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| WGK Germany | 3 |
|---|
Articles1
More Articles
| A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro. J. Biol. Chem. 272 , 13432-13436, (1997) The apoptotic cysteine protease, caspase-3, is expressed in cells as an inactive 32-kDa precursor from which 17 kDa (p17) and 12 kDa (p12) subunits of the mature caspase-3 are proteolytically generate... | |
Synonyms
| MFCD01318832 |
| (4S)-5-[[(2S,3R)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoic acid |
| Cbz-IETD-AFC |
| Z-Ile-Glu-Thr-Asp-AFC |
| Z-IETD-AFC |
