CAS 85371-64-8|Pinacidil hydrate
| Common Name | Pinacidil hydrate | ||
|---|---|---|---|
| CAS Number | 85371-64-8 | Molecular Weight | 263.34 |
| Density | / | Boiling Point | 356.7ºC at 760 mmHg |
| Molecular Formula | C13H21N5O | Melting Point | 164-165ºC |
| MSDS | ChineseUSA | Flash Point | 169.5ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Pinacidil |
|---|---|
| Synonym | More Synonyms |
Pinacidil hydrate BiologicalActivity
| Description | Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Potassium ChannelResearch Areas >>Others |
| In Vitro | Pinacidil monohydrate is a potassium channel activator[1]. Pinacidil hydrate is an antihypertensive drug of the class of agents called "potassium channel openers"[2]. Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with Ki values of 104 and 251 nM, respectively[3]. |
| References | [1]. Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86. [2]. Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5. [3]. Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92. |
Chemical & Physical Properties
| Boiling Point | 356.7ºC at 760 mmHg |
|---|---|
| Melting Point | 164-165ºC |
| Molecular Formula | C13H21N5O |
| Molecular Weight | 263.34 |
| Flash Point | 169.5ºC |
| PSA | 73.10000 |
| LogP | 2.94578 |
| InChIKey | AFJCNBBHEVLGCZ-UHFFFAOYSA-N |
| SMILES | CC(N=C(NC#N)Nc1ccncc1)C(C)(C)C.O |
| Storage condition | 2-8℃ |
| Water Solubility | ethanol: 14 mg/mL |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Pinacidil (hydrate) |
| Pinacidil . monohydrate |
| 1-Cyano-3-(3,3-dimethylbutan-2-yl)-2-pyridin-4-ylguanidine hydrate (1:1) |
| (+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine |
| MFCD00242745 |
| Hndac |
| GUANIDINE,N-CYANO-N'-4-PYRIDINYL-N''-(1,2,2-TRIMETHYLPROPYL)-, HYDRATE (1:1) |
| Guanidine, N''-cyano-N-4-pyridinyl-N'-(1,2,2-trimethylpropyl)-, hydrate (1:1) |
| Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-,monohydrate |
| Pinacidil monohydrate |
| EINECS 262-294-9 |
| Pinacidil hydrate |
| 1-Cyano-2-(3,3-dimethyl-2-butanyl)-3-(4-pyridinyl)guanidine hydrate (1:1) |
