CAS 53-84-9|NAD+
| Common Name | NAD+ | ||
|---|---|---|---|
| CAS Number | 53-84-9 | Molecular Weight | 663.425 |
| Density | / | Boiling Point | / |
| Molecular Formula | C21H27N7O14P2 | Melting Point | 140 - 142ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS08 | Signal Word | Warning |
Names
| Name | NAD zwitterion |
|---|---|
| Synonym | More Synonyms |
NAD+ BiologicalActivity
| Description | NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseNatural Products >>Saccharides and Glycosides |
| Target | Human Endogenous Metabolite |
| In Vitro | NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NAD+ is the oxidized form of NADH[1]. NAD+ is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide) [2]. |
| In Vivo | Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia[3]. |
| References | [1]. Viollet, B., et al., Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond), 2012. 122(6): p. 253-70. [2]. Brandt, U., Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem, 2006. 75: p. 69-92. [3]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12. |
Chemical & Physical Properties
| Melting Point | 140 - 142ºC |
|---|---|
| Molecular Formula | C21H27N7O14P2 |
| Molecular Weight | 663.425 |
| Exact Mass | 663.109131 |
| PSA | 340.71000 |
| LogP | -5.72 |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-O |
| SMILES | NC(=O)c1ccc[n+](C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(n4cnc5c(N)ncnc54)C(O)C3O)C(O)C2O)c1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4333 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 45,327,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3384 No. of Facilities: 499 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4168 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3384 No. of Facilities: 1731 (estimated) No. of Industries: 5 No. of Occupations: 13 No. of Employees: 26664 (estimated) No. of Female Employees: 19782 (estimated)
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 45,327,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3384 No. of Facilities: 499 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4168 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3384 No. of Facilities: 1731 (estimated) No. of Industries: 5 No. of Occupations: 13 No. of Employees: 26664 (estimated) No. of Female Employees: 19782 (estimated)
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H371 |
| Precautionary Statements | P260 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn,F,Xi |
| Risk Phrases | R36 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UU3450000 |
| HS Code | 29349990 |
Customs
| HS Code | 29349990 |
|---|
Articles286
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| L-lactate production from biodiesel-derived crude glycerol by metabolically engineered Enterococcus faecalis: cytotoxic evaluation of biodiesel waste and development of a glycerol-inducible gene expression system. Appl. Environ. Microbiol. 81(6) , 2082-9, (2015) Biodiesel waste is a by-product of the biodiesel production process that contains a large amount of crude glycerol. To reuse the crude glycerol, a novel bioconversion process using Enterococcus faecal... |
Synonyms
| b-Diphosphopyridine Nucleotide |
| DPN |
| beta-Diphosphopyrid |
| MFCD00036253 |
| Coenzyme I Hydrate,oxidized form |
| Diphosphopyridine nucleotide |
| Cozymase Hydrate,oxidized form |
| β-Nicotinamide adenine dinucleotide |
| EINECS 200-184-4 |
| β-Diphosphopyridine Nucleotide Hydrate,oxidized form |
| β-NAD Hydrate,oxidized form |
| Adenine-D-ribose-phosphate-phosphate-D-ribose-nicotinamide |
| b-Nicotinamide Adenine Dinucleotide |
| β-DPN Hydrate,oxidized form |
| Adenosine 5'-(Trihydrogen Diphosphate) P'®5'-ester with 3-(Aminocarbonyl)-1-b-D-ribofuranosylpyridinium hydroxide Inner Salt |
| Codehydrogenase |
| β-Nicotinamide Adenine Dinucleotide Hydrate,oxidized form |
| 3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'®5'-ester with Adenosine 5'-(Trihydrogen Pyrophosphate) Inner Salt |
| ARPPRN |
| b-NAD |
| Cozymase |
| beta-Diphosphopyridine nucleotide |
| β-NAD |
| β-Nicotinamide adenine dinucleotide hydrate |
| NAD |
| β-DPN |
| NAD+ |
