CAS 90-94-8|Michler's ketone

Introduction：Basic information about CAS 90-94-8|Michler's ketone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles14
7. Synonyms

Common Name	Michler's ketone
CAS Number	90-94-8	Molecular Weight	268.353
Density	1.1±0.1 g/cm3	Boiling Point	427.7±30.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₀N₂O	Melting Point	174 -176 °C(lit.)
MSDS	ChineseUSA	Flash Point	183.9±16.9 °C
Symbol	GHS05, GHS08	Signal Word	Danger

Names

Name	4,4'-Bis(dimethylamino)benzophenone
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	427.7±30.0 °C at 760 mmHg
Melting Point	174 -176 °C(lit.)
Molecular Formula	C₁₇H₂₀N₂O
Molecular Weight	268.353
Flash Point	183.9±16.9 °C
Exact Mass	268.157562
PSA	23.55000
LogP	3.87
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.612
InChIKey	VVBLNCFGVYUYGU-UHFFFAOYSA-N
SMILES	CN(C)c1ccc(C(=O)c2ccc(N(C)C)cc2)cc1
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents.
Water Solubility	400 mg/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ0250000

CHEMICAL NAME :: Benzophenone, 4,4'-bis(dimethylamino)-

CAS REGISTRY NUMBER :: 90-94-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C17-H20-N2-O

MOLECULAR WEIGHT :: 268.39

WISWESSER LINE NOTATION :: 1N1&R D- 2V

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 164 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1500 ug/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,17,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1044 No. of Facilities: 174 (estimated) No. of Industries: 7 No. of Occupations: 11 No. of Employees: 2026 (estimated) No. of Female Employees: 405 (estimated)

Safety Information

Symbol	GHS05, GHS08
Signal Word	Danger
Hazard Statements	H318-H341-H350
Precautionary Statements	P201-P280-P305 + P351 + P338-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R41;R45;R68
Safety Phrases	S53-S45
RIDADR	2811
WGK Germany	3
RTECS	DJ0250000
Packaging Group	III
Hazard Class	6.1
HS Code	2922399090

Customs

HS Code	2922399090
Summary	2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles14

Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment.

Environ. Sci. Technol. 41(9) , 3269-76, (2007)

Bioaccumulation in fish depends on the dynamics of various processes that involve fish uptake, storage, and elimination of xenobiotics. Elimination via fish biotransformation is a primary process that...

A comparison of the mutagenicity and macromolecular binding of the carcinogens Michler's ketone and reduced Michler's ketone.

Mutat. Res. 119(1) , 7-14, (1983)

The mutagenicity of 4,4'-bis(dimethylamino)benzophenone (Michler's ketone, MK, CAS No. 90-94-8) and 4,4'-methylenebis(N,N-dimethyl)benzamine (reduced Michler's ketone, RMK, CAS No. 101-61-1) for Salmo...

Michler's ketone.

Rep. Carcinog. 12 , 270-1, (2011)

Synonyms

4,4'-Bis(dimethylamino)benzophenone

Bis[p-(N,N-dimethylamino)phenyl] ketone

EINECS 202-027-5

Methanone, bis[4- (dimethylamino)phenyl]-

Methanone, bis[4-(dimethylamino)phenyl]-

Bis[4-(dimethylamino)phenyl]methanone

Michler's ketone

MFCD00008312

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