Introduction：Basic information about CAS 2624-44-4|Etamsylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Etamsylate |
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| CAS Number | 2624-44-4 | Molecular Weight | 263.311 |
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| Density | / | Boiling Point | 496.4ºC at 760 mmHg |
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| Molecular Formula | C10H17NO5S | Melting Point | 127-131ºC |
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| MSDS | / | Flash Point | 254ºC |
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Names
| Name | 2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine (1:1) |
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| Synonym | More Synonyms |
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Etamsylate BiologicalActivity
| Description | Ethamsylate is a haemostatic drug, also inhibits biosynthesis and action of those prostaglandins. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Cardiovascular Disease |
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Chemical & Physical Properties
| Boiling Point | 496.4ºC at 760 mmHg |
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| Melting Point | 127-131ºC |
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| Molecular Formula | C10H17NO5S |
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| Molecular Weight | 263.311 |
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| Flash Point | 254ºC |
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| Exact Mass | 263.082733 |
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| PSA | 115.24000 |
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| LogP | 2.43200 |
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| Vapour Pressure | 1.13E-10mmHg at 25°C |
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| InChIKey | HBGOLJKPSFNJSD-UHFFFAOYSA-N |
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| SMILES | CCNCC.O=S(=O)(O)c1cc(O)ccc1O |
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| Storage condition | 2~8 ℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DB6145000
- CHEMICAL NAME :
- Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine
- CAS REGISTRY NUMBER :
- 2624-44-4
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C6-H6-O5-S.C4-H11-N
- MOLECULAR WEIGHT :
- 263.34
- WISWESSER LINE NOTATION :
- WSQR BQ EQ &2M2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 29750 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6040 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 760 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 3500 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement
MUTATION DATA - TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Mold - Aspergillus nidulans
- DOSE/DURATION :
- 1 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2921199090 |
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Customs
| HS Code | 2922299090 |
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| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles25
More Articles
| Application and equivalence assessment for determining ethamsylate by using potassium ferricyanide as spectroscopic probe reagent. Anal. Sci. 26(11) , 1163-7, (2010) In this paper, a novel method has been established to determine ethamsylate using potassium ferricyanide as a spectroscopic probe reagent. It has been demonstrated that Fe(III) is reduced to Fe(II) by... | |
| Simultaneous determination of aminomethylbenzoic acid, cefminox sodium and etamsylate in human urine by capillary electrophoresis. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(21) , 1899-903, (2010) A sensitive and selective capillary electrophoresis method is developed, for the first time, for effective separation and simultaneous determination of aminomethylbezoic acid (PAMBA), cefminox sodium ... | |
| A novel visible spectrophotometric method for the determination of ethamsylate in pharmaceutical preparations and biological samples. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 75(3) , 1013-7, (2010) A highly sensitive visible spectrophotometric method has been developed to determine ethamsylate in this paper, which is based on using Cu(II) as spectroscopic probe reagent. The study indicates that ... | |
Synonyms
| Diethylamine 2,5-Dihydroxybenzenesulfonate |
| 1-Hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic Acid Compd with Diethylamine |
| 2,5-Dihydroxybenzenesulfonic acid - N-ethylethanamine (1:1) |
| MFCD00867499 |
| Etamsylate |
| EINECS 220-090-7 |
| Ethamsylate |
| 2,5-Dihydroxybenzenesulfonic Acid Compd with N-Ethylethanamine |
| Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1) |
| Benzenesulfonic acid,2,5-dihydroxy-,compd. with N-ethylethanamine |
