CAS 83-48-7|Stigmasterol
Introduction：Basic information about CAS 83-48-7|Stigmasterol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Stigmasterol | ||
|---|---|---|---|
| CAS Number | 83-48-7 | Molecular Weight | 412.691 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 501.1±19.0 °C at 760 mmHg |
| Molecular Formula | C29H48O | Melting Point | 165-167 °C(lit.) |
| MSDS | USA | Flash Point | 219.4±13.7 °C |
| Symbol | GHS06, GHS08 | Signal Word | Danger |
Names
| Name | stigmasterol |
|---|---|
| Synonym | More Synonyms |
Stigmasterol BiologicalActivity
| Description | Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. |
|---|---|
| Related Catalog | Natural Products >>SteroidsResearch Areas >>Inflammation/Immunology |
| Target | MMP[1] |
| In Vitro | Preincubation of Stigmasterol to IL-1beta-treated cells shows significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1]. |
| Cell Assay | A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1]. |
| References | [1]. Gabay O, et al. Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage. 2010 Jan;18(1):106-16. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 501.1±19.0 °C at 760 mmHg |
| Melting Point | 165-167 °C(lit.) |
| Molecular Formula | C29H48O |
| Molecular Weight | 412.691 |
| Flash Point | 219.4±13.7 °C |
| Exact Mass | 412.370514 |
| PSA | 20.23000 |
| LogP | 10.21 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | 2~8°C |
| Water Solubility | insoluble |
Safety Information
| Symbol | GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H319-H331-H336-H351-H361d-H372 |
| Precautionary Statements | P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn,Xi |
| Risk Phrases | R22 |
| Safety Phrases | S22-S24/25-S36/37 |
| RIDADR | UN 1888 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 2906199090 |
Customs
| HS Code | 2906199090 |
|---|---|
| Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| (24S)-5,22-Stigmastadien-3b-ol |
| Stigmasta-5,22-dien-3-ol, (3β,22E)- |
| STIGMASTEROL (STIGMASTERIN) |
| (24S)-Stigmast-5,22-dien-3β-ol |
| STIGMASTEROL(P) |
| Wulzen anti-stiffness factor |
| Guinea-pig-anti-stiffness factor |
| SULFISOXAZOLE |
| Stigmasta-5,22-dien-3-ol, (3β,22E)- (9CI) |
| Stigmasta-5,22-dien-3β-ol |
| Stigmasterol |
| δ5,22-Stigmastadien-3β-ol |
| Anti-stiffness factor |
| (3β,22E)-Stigmasta-5,22-dien-3-ol |
| Stigmasta-5,22-dien-3-ol, (3β)- |
| Stigmasta-5,22-dien-3-ol, (3β,20R,22E,24S)- |
| MFCD00003630 |
| Stigmasta-5,22-dien-3β-ol (8CI) |
| Stigmasta-5,22E-dien-3β-ol |
| isofucosterol |
| stigmasta-5,22-dien-3-b-ol |
| Stigmastero |
| STIGMASTA-5,22-DIEN-3-OL,(3B,22E)- |
| EINECS 201-482-7 |
| Stigmasterin |
| (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-Ethyl-6-methyl-3-hepten-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| (3β,20R,22E,24S)-Stigmasta-5,22-dien-3-ol |
| 3b-Hydroxy-24-ethyl-D5,22-cholestadiene |
| δ5-Stigmasterol |
| 24S-ethylcholest-5,22-dien-3β-ol |
| stigmasta-5,22-dien-3-β-ol |
| β-Stigmasterol |
| (24S)-5,22-Stigmastadien-3β-ol |
| (3b,22E)-Stigmasta-5,22-dien-3-ol |
| 5,22-stigmastadien-3β-ol |
| (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| PHYTOSTEROL |
| UNII-99WUK5D0Y8 |
| (24S)-24-Ethylcholesta-5,22-dien-3β-ol |
