CAS 532-43-4|Thiamine nitrate

Introduction：Basic information about CAS 532-43-4|Thiamine nitrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Thiamine nitrate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles1
8. Synonyms

Common Name	Thiamine nitrate
CAS Number	532-43-4	Molecular Weight	327.359
Density	/	Boiling Point	/
Molecular Formula	C₁₂H₁₇N₅O₄S	Melting Point	196-200°C
MSDS	ChineseUSA	Flash Point	/

Names

Name	Thiamine nitrate
Synonym	More Synonyms

Thiamine nitrate BiologicalActivity

Description	Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
In Vitro	Thiamine levels in the blood of homozygous KO and KI mice fed a conventional diet are decreased to 0.058±0.051 and 0.126±0.092 μM, respectively, at 7 weeks compare to WT mice (0.796±0.259 μM). When WT and homozygous KO and KI mice are fed a Thiamine-restricted diet (Thiamine: 0.60 mg/100 g food), blood Thiamine concentration at 5 and 14 days is markedly decreased to 0.010±0.009 and 0.010±0.006 μM, respectively, compare to WT mice (0.609±0.288 μM). Thiamine concentration in brain homogenate of WT mice fed a conventional diet is 3.81±2.18 nmol/g wet weight, and that of KO and KI is 1.33±0.96 and 2.16±1.55 nmol/g wet weight, respectively. Notably, Thiamine concentration in brain homogenate decreases steadily in KO and KI mice fed a thiamine-restrict diet (Thiamine: 0.60 mg/100 g food) for 5 days (0.95±0.72 nmol/g wet weight) and 14 days (1.11±0.24 nmol/g wet weight), respectively, compare to WT (3.65±1.02 nmol/g wet weight), before the mice presenting an phenotype of disease[2].
In Vivo	WT, homozygous, and heterozygous KO and KI mice fed a conventional diet (thiamine: 1.71 mg/100 g) survive for over 6 months without any phenotype of disease. Homozygous KO and KI mice fed a Thiamine-restricted diet (thiamine: 0.60 mg/100 g food) show paralysis, weight loss, and immobility, and die within 12 and 30 days, respectively. Similarly, homozygous KO and KI mice fed a Thiamine-restricted diet with an even lower percentage of Thiamine (Thiamine: 0.27 mg/100 g food) die within 14 and 18 days, respectively. However, WT and heterozygous KO and KI mice fed a Thiamine-restricted diet (Thiamine: 0.60 mg or 0.27 mg/100g food) survive for over 6 months without any phenotype of disease[2].
Animal Admin	Slc19a3 E314Q KI mice are maintained routinely with conventional diet, which has a Thiamine concentration (thiamine hydrochloride, MW=337.3) of 1.71 mg/100 g food. Two types of Thiamine-restrict food base on “purified diets for laboratory rodents” are prepared, in which Thiamine concentration is 0.60 mg/100 g food (35% Thiamine of conventional food) or 0.27 mg/100 g food (16% Thiamine of conventional food). A high-Thiamine-containing food is also prepared from AIN-93M, in which Thiamine concentration is five times that of CE-2 (thiamine: 8.50 mg/100 g food)[2].
References	[1]. Kenneth Osiezagha, et al.Thiamine Deficiency and Delirium. Innov Clin Neurosci. 2013 Apr; 10(4): 26-32. [2]. Kaoru Suzuki, et al. High-dose thiamine prevents brain lesions and prolongs survival ofSlc19a3-deficient mice. PLoS One. 2017; 12(6): e0180279.

Chemical & Physical Properties

Melting Point	196-200°C
Molecular Formula	C₁₂H₁₇N₅O₄S
Molecular Weight	327.359
Exact Mass	327.100128
PSA	173.03000
LogP	1.47300
InChIKey	UIERGBJEBXXIGO-UHFFFAOYSA-N
SMILES	Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1.O=[N+]([O-])[O-]
Stability	Stable. Incompatible with strong oxidizing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI7400000

CHEMICAL NAME :: Thiamine, nitrate

CAS REGISTRY NUMBER :: 532-43-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H17-N4-O-S.N-O3

MOLECULAR WEIGHT :: 327.40

WISWESSER LINE NOTATION :: T6N CNJ B1 DZ E1- AT5K CSJ D2Q E1 &Q &N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,114,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 387 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,449,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,449,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80545 No. of Facilities: 177 (estimated) No. of Industries: 4 No. of Occupations: 12 No. of Employees: 15363 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80545 No. of Facilities: 1106 (estimated) No. of Industries: 8 No. of Occupations: 36 No. of Employees: 39898 (estimated) No. of Female Employees: 18813 (estimated)

Safety Information

Hazard Codes	Xn
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
RTECS	XI7400000
HS Code	2934100090

Customs

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles1

Stability of hydrophilic vitamins mixtures in the presence of electrolytes and trace elements for parenteral nutrition: a nuclear magnetic resonance spectroscopy investigation.

J. Pharm. Biomed. Anal. 107 , 7-10, (2015)

In total parenteral nutrition (TPN), especially in the case of preterm infants, simultaneous administration of vitamins and trace elements is still a problematic issue: guidelines put in evidence the ...

Synonyms

EINECS 208-537-4

MFCD00036330

Thiamin mononitrate

Thiaminenitrate

thiamin nitrate

Thiamine nitrate,Vitamin B1 nitrate

Vitamin B1 Mono

thiamine,nitrate

Vitamin B1 nitrate

Thiamine Nitrate

Vitanon

Thaimenitrate

thiaminium nitrate

Thiaminnitrat

VitaMin B1 HNO3

mnitrate

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