Introduction：Basic information about CAS 84392-17-6|XENALIPIN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | XENALIPIN |
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| CAS Number | 84392-17-6 | Molecular Weight | 266.215 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 335.8±37.0 °C at 760 mmHg |
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| Molecular Formula | C14H9F3O2 | Melting Point | 169-171 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 156.9±26.5 °C |
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Names
| Name | 4-(Trifluoromethyl)biphenyl-2-carboxylic acid |
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| Synonym | More Synonyms |
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XENALIPIN BiologicalActivity
| Description | 4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vivo | 4'-Trifluoromethyl-2-biphenyl carboxylic acid (15-60 mg/kg, p.o., twice a day) shows hypolipidemic activity in diet-induced hypercholesterolemic African green monkeys[1]. Animal Model: Diet-induced hypercholesterolemic African green monkeys[5] Dosage: 15-60 mg/kg Administration: Oral administration (p.o.) Result: Reduced serum LDL-cholesterol concentrations. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 335.8±37.0 °C at 760 mmHg |
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| Melting Point | 169-171 °C(lit.) |
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| Molecular Formula | C14H9F3O2 |
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| Molecular Weight | 266.215 |
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| Flash Point | 156.9±26.5 °C |
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| Exact Mass | 266.055450 |
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| PSA | 37.30000 |
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| LogP | 3.97 |
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| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
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| Index of Refraction | 1.538 |
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| InChIKey | IQOMYCGTGFGDFN-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1ccccc1-c1ccc(C(F)(F)F)cc1 |
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| Storage condition | Room temperature. |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36/37/39 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2916399090 |
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Customs
| HS Code | 2916399090 |
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| Summary | 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Articles3
More Articles
| Evaluation of the hypolipidemic activity of xenalipin in experimental animals. Atherosclerosis 64(1) , 27-35, (1987) Xenalipin (4'-trifluoromethyl-2-biphenylcarboxylic acid) is a chemically novel compound which has been found to be an effective hypolipidemic agent in two animal species. Significant reductions in ser... | |
| The Nickel (I) Catalyzed Coupling of a Diarylzinc with an Aryl Chloride in the Synthesis of Xenalipin. Eaddy JF. Org. Prep. Proced. Int. 27(3) , 367-72, (1995)
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| Synthesis of carbon-14 labelled xenalipin-a potential hypolipidemic agent.Hill JA and Eaddy JF. J. Labelled Comp. Radiopharm. 31(12) , 1011-17, (1992)
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Synonyms
| XENALIPIN |
| 4'-(Trifluoromethyl)-2-biphenylcarboxylic acid |
| 4'-(trifluoromethyl)biphenyl-2-carboxylic acid |
| 2-[4-(trifluoromethyl)phenyl]benzoic acid |
| MFCD00075353 |
| [1,1'-Biphenyl]-2-carboxylic acid, 4'-(trifluoromethyl)- |
| 4'-(Trifluoromethyl)-1,1'-biphenyl-2-carboxylic Acid |
| 4-(Trifluoromethyl)-2'-biphenylcarboxylic acid |
