CAS 68497-62-1|pramiracetam

Introduction：Basic information about CAS 68497-62-1|pramiracetam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. pramiracetam BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles23
7. Synonyms

Common Name	pramiracetam
CAS Number	68497-62-1	Molecular Weight	269.383
Density	1.0±0.1 g/cm3	Boiling Point	461.0±30.0 °C at 760 mmHg
Molecular Formula	C₁₄H₂₇N₃O₂	Melting Point	47 °C
MSDS	ChineseUSA	Flash Point	232.6±24.6 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	Pramiracetam Hydrate
Synonym	More Synonyms

pramiracetam BiologicalActivity

Description	Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries. IC50 Value: Target: in vitro: Pramiracetam sulfate did not exhibit any affinity in vitro for dopaminergic , GABAergic, serotoninergic, adrenergic, muscarinic, adenosine (IC50 > 10 uM), and benzodiazepine receptors (IC50 > 1 uM) binding sites [1].in vivo: In a double-blind, randomized design, two groups of six subjects each received alternating placebo and single 400, 800, 1,200, and 1,600 mg oral doses of pramiracetam after an overnight fast. Mean (+/- SD) peak plasma concentrations of the four dose groups (2.71 +/- 0.54, 5.40 +/- 1.34, 6.13 +/- 0.71, 8.98 +/- 0.71 micrograms/mL) were attained between two to three hours following drug administration [2]. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food [3].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Warner Lambert, et al. Some Neurochemical Properties of Pramiracetam (CI-879), A New Cognition-Enhancing Agent. [2]. Chang T, et al. Pharmacokinetics of oral pramiracetam in normal volunteers. J Clin Pharmacol. 1985 May-Jun;25(4):291-5.

Description

Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries. IC50 Value: Target: in vitro: Pramiracetam sulfate did not exhibit any affinity in vitro for dopaminergic , GABAergic, serotoninergic, adrenergic, muscarinic, adenosine (IC50 > 10 uM), and benzodiazepine receptors (IC50 > 1 uM) binding sites [1].in vivo: In a double-blind, randomized design, two groups of six subjects each received alternating placebo and single 400, 800, 1,200, and 1,600 mg oral doses of pramiracetam after an overnight fast. Mean (+/- SD) peak plasma concentrations of the four dose groups (2.71 +/- 0.54, 5.40 +/- 1.34, 6.13 +/- 0.71, 8.98 +/- 0.71 micrograms/mL) were attained between two to three hours following drug administration [2]. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food [3].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Warner Lambert, et al. Some Neurochemical Properties of Pramiracetam (CI-879), A New Cognition-Enhancing Agent.

[2]. Chang T, et al. Pharmacokinetics of oral pramiracetam in normal volunteers. J Clin Pharmacol. 1985 May-Jun;25(4):291-5.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	461.0±30.0 °C at 760 mmHg
Melting Point	47 °C
Molecular Formula	C₁₄H₂₇N₃O₂
Molecular Weight	269.383
Flash Point	232.6±24.6 °C
Exact Mass	269.210327
PSA	52.65000
LogP	0.39
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.495
InChIKey	ZULJGOSFKWFVRX-UHFFFAOYSA-N
SMILES	CC(C)N(CCNC(=O)CN1CCCC1=O)C(C)C
Storage condition	2-8°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport
HS Code	2942000000

Customs

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles23

The effects of cholinergic drugs support an avoidance learning hypothesis of brief footshock-induced analgesia.

Neuropharmacology 25(10) , 1161-6, (1986)

Rats were tested for tail-flick responses and then immediately subjected to footshock for 30 sec. This procedure induced analgesia, i.e. prolonged the latency of the tail-flick response, which was max...

The memory-enhancing effects of the piracetam-like nootropics are dependent on experimental parameters.

Behav. Brain Res. 33(1) , 79-82, (1989)

The effects of the nootropic agent piracetam and its congeners oxiracetam, pramiracetam and aniracetam on the retention performance of mice in a passive-avoidance situation are dependent on the intens...

Gas chromatographic assay of pramiracetam in human plasma using nitrogen specific detection.

J. Chromatogr. A. 274 , 346-9, (1983)

Synonyms

N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide

Neupramir

Pramiracetam

Pramistar

Remen

Amacetam

N-[2-(Diisopropylamino)ethyl]-2-(2-oxo-1-pyrrolidinyl)acetamide

1-Pyrrolidineacetamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo-

MFCD00867219

N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide

N-[2-(dipropan-2-ylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide

N-[2-[Bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide

N-[2-(Diisopropylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide

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