Introduction：Basic information about CAS 15687-37-3|naftazone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | naftazone |
|---|
| CAS Number | 15687-37-3 | Molecular Weight | 215.20800 |
|---|
| Density | 1.4g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C11H9N3O2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | [(E)-(1-oxonaphthalen-2-ylidene)amino]urea |
|---|
| Synonym | More Synonyms |
|---|
naftazone BiologicalActivity
| Description | Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation[1][2]. |
|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
|---|
| In Vitro | Naftazone (0.5-50 μM; 1 h) reduces glutamate release from mouse cerebellum synaptosomes[1]. |
|---|
| In Vivo | Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid[1]. Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats[2]. Animal Model: Male rats[1] Dosage: 10 and 100 mg/kg Administration: Oral gavage; 10 and 100 mg/kg once per day; for 15 days Result: Significantly reduced glutamate content in cerebro spinal fluid of rats. Animal Model: Wistar rats[2] Dosage: 50 mg/kg Administration: Intraperitoneal injection ; 50 mg/kg once daily for 5 days Result: Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet. |
|---|
Chemical & Physical Properties
| Density | 1.4g/cm3 |
|---|
| Molecular Formula | C11H9N3O2 |
|---|
| Molecular Weight | 215.20800 |
|---|
| Exact Mass | 215.06900 |
|---|
| PSA | 84.55000 |
|---|
| LogP | 2.01160 |
|---|
| Index of Refraction | 1.678 |
|---|
| InChIKey | AGSIRJFXAANBMW-UHFFFAOYSA-N |
|---|
| SMILES | NC(=O)N=Nc1ccc2ccccc2c1O |
|---|
Safety Information
Customs
| HS Code | 2928000090 |
|---|
| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
|---|
Synonyms
| Mediaven |
| Naftazone (INN) |
| Naftazona |
| Naftazonum |
| Naftazone |
| 1,2-Naphthochinon-2-semicarbazon |
| [1,2]naphthoquinone-2-semicarbazone |
| Mediavene |
| 1,2-naphthoquinone semicarbazone |
| Karbinone |
| Mediaven (TN) |
