Introduction：Basic information about CAS 147-20-6|diphenylpyraline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | diphenylpyraline |
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| CAS Number | 147-20-6 | Molecular Weight | 281.39200 |
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| Density | 1.08 g/cm3 | Boiling Point | 378.7ºC at 760 mmHg |
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| Molecular Formula | C19H23NO | Melting Point | / |
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| MSDS | / | Flash Point | 111.6ºC |
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Names
| Name | diphenylpyraline |
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| Synonym | More Synonyms |
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diphenylpyraline BiologicalActivity
| Description | Diphenylpyraline is a potent histamine H1 receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| Target | H1 Receptor |
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| In Vitro | Diphenylpyraline (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices[2]. |
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| In Vivo | Diphenylpyraline (intraperitoneal injection; 5-10 mg/kg) elevates extracellular dopamine levels (~200%) in mouse nucleus accumbens and induces locomotor activation in mice[2]. Animal Model: C57BL/6 mice[2] Dosage: 5-10 mg/kg Administration: Intraperitoneal injection Result: Had psychostimulant properties. |
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| References | [1]. Erik B Oleson, et al. Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. [2]. Gennady B Lapa, et al. Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties. |
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Chemical & Physical Properties
| Density | 1.08 g/cm3 |
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| Boiling Point | 378.7ºC at 760 mmHg |
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| Molecular Formula | C19H23NO |
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| Molecular Weight | 281.39200 |
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| Flash Point | 111.6ºC |
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| Exact Mass | 281.17800 |
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| PSA | 12.47000 |
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| LogP | 3.82470 |
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| Vapour Pressure | 6.18E-06mmHg at 25°C |
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| Index of Refraction | 1.587 |
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| InChIKey | OWQUZNMMYNAXSL-UHFFFAOYSA-N |
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| SMILES | CN1CCC(OC(c2ccccc2)c2ccccc2)CC1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TM7810000
- CHEMICAL NAME :
- Piperidine, 4-(diphenylmethoxy)-1-methyl-
- CAS REGISTRY NUMBER :
- 147-20-6
- BEILSTEIN REFERENCE NO. :
- 0245467
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C19-H23-N-O
- MOLECULAR WEIGHT :
- 281.43
- WISWESSER LINE NOTATION :
- T6NTJ A1 DOYR&R
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 50,459,1979 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,155,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84788 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 62 (estimated)
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Safety Information
| Hazard Codes | Xn |
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| RIDADR | UN 3249 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2933399090 |
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Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Hispril |
| N-methyl-4-(diphenylmethoxy)piperidine |
| Neargal |
| Lergobine |
| EINECS 205-686-7 |
| Belfene |
| Dayfen |
| 4-benzhydryloxy-1-methyl-piperidine |
| Histyn |
| Mepiben |
| 4-Benzhydryloxy-1-methyl-piperidin |
| 4-Diphenylmethoxy-1-methyl-piperidin |
| 4-(diphenylmethoxy)-1-methylpiperidine |
| Lyssipoll |
| Allergen |
| 4-benzhydryloxy-1-methylpiperidine |
