Introduction:Basic information about CAS 85-73-4|Phthalylsulfathiazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Phthalylsulfathiazole |
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| CAS Number | 85-73-4 | Molecular Weight | 403.432 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 579ºC at 760 mmHg |
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| Molecular Formula | C17H13N3O5S2 | Melting Point | 198-204°C |
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| MSDS | USA | Flash Point | 304ºC |
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Names
| Name | Phthalylsulfathiazole |
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| Synonym | More Synonyms |
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Phthalylsulfathiazole BiologicalActivity
| Description | Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Others |
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| References | [1]. S. RAGHAV, et al. Kinetics of Xylene Coagulation in Water Emulsion Stabilized by Phthalylsulfathiazole. ACS Symposium Series, 1985: 447-460 |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 579ºC at 760 mmHg |
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| Melting Point | 198-204°C |
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| Molecular Formula | C17H13N3O5S2 |
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| Molecular Weight | 403.432 |
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| Flash Point | 304ºC |
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| Exact Mass | 403.029663 |
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| PSA | 162.08000 |
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| LogP | 1.54 |
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| Index of Refraction | 1.715 |
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| InChIKey | PBMSWVPMRUJMPE-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1ccccc1C(=O)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 |
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| Storage condition | -20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TH8575000
- CHEMICAL NAME :
- Phthalanilic acid, 4'-(2-thiazolylsulfamoyl)-
- CAS REGISTRY NUMBER :
- 85-73-4
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C17-H13-N3-O5-S2
- MOLECULAR WEIGHT :
- 403.45
- WISWESSER LINE NOTATION :
- T5N CSJ BMSWR DMVR BVQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 920 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12900 mg/kg/30D-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of esophagus
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84641 No. of Facilities: 193 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 9471 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84641 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | 3249 |
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| RTECS | TH8575000 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2935009090 |
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Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Articles25
More Articles
| [Experimental basis for the tentative permissible levels of phthalazol, sulfadimethoxine and Bepask in bodies of water]. Gig. Sanit. (12) , 9-10, (1993) Tentative permissible levels (TPL) of phthalazol, sulfadimethoxine, and Bepask in the water were substantiated on the basis of study of organoleptic properties, of influence on sanitary status of wate... | |
| The effect of antibacterial agents on the intestinal flora of patients: the use of aureomycin, chloromycetin, dihydrostreptomycin, sulfasuxidine and sulfathalidine. Gastroenterology 16(1) , 12-8, (1950)
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| The effects of phthalylsulphathiazole on the bacteria of the colonic mucosa and intestinal contents as revealed by the examination of surgical samples. Scand. J. Gastroenterol. 14(7) , 891-6, (1979) The isolation of a bacterial flora specifically associated with the colonic mucosa of patients undergoing large-bowel surgery is described. This flora differed from that of faeces in both the numbers ... | |
Synonyms
| Cremothalidine |
| Phthalylsulfathiazole |
| Taloudron |
| Ftalazol |
| 2-[({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)carbonyl]benzoic acid |
| N-(4-thiazol-2-ylsulfamoyl-phenyl)-phthalamic acid |
| Talidine |
| entexidin |
| Phtalazol |
| N-(4-Thiazol-2-ylsulfamoyl-phenyl)-phthalamidsaeure |
| EINECS 201-627-4 |
| Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]- |
| Sulftalyl |
| PST |
| 2-[({4-[(2-thiazolylamino)sulfonyl]phenyl}amino)carbonyl]-benzoic acid |
| Thalinil |
| Ftalysept |
| 2-{[4-(1,3-Thiazol-2-ylsulfamoyl)phenyl]carbamoyl}benzoic acid |
| MFCD00005318 |
| Taleudron |