CAS 85-73-4|Phthalylsulfathiazole

Introduction:Basic information about CAS 85-73-4|Phthalylsulfathiazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NamePhthalylsulfathiazole
CAS Number85-73-4Molecular Weight403.432
Density1.6±0.1 g/cm3Boiling Point579ºC at 760 mmHg
Molecular FormulaC17H13N3O5S2Melting Point198-204°C
MSDSUSAFlash Point304ºC

Names

NamePhthalylsulfathiazole
SynonymMore Synonyms

Phthalylsulfathiazole BiologicalActivity

DescriptionPhthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug.
Related CatalogSignaling Pathways >>Anti-infection >>BacterialResearch Areas >>Others
References

[1]. S. RAGHAV, et al. Kinetics of Xylene Coagulation in Water Emulsion Stabilized by Phthalylsulfathiazole. ACS Symposium Series, 1985: 447-460

Chemical & Physical Properties

Density1.6±0.1 g/cm3
Boiling Point579ºC at 760 mmHg
Melting Point198-204°C
Molecular FormulaC17H13N3O5S2
Molecular Weight403.432
Flash Point304ºC
Exact Mass403.029663
PSA162.08000
LogP1.54
Index of Refraction1.715
InChIKeyPBMSWVPMRUJMPE-UHFFFAOYSA-N
SMILESO=C(O)c1ccccc1C(=O)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1
Storage condition-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TH8575000
CHEMICAL NAME :
Phthalanilic acid, 4'-(2-thiazolylsulfamoyl)-
CAS REGISTRY NUMBER :
85-73-4
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C17-H13-N3-O5-S2
MOLECULAR WEIGHT :
403.45
WISWESSER LINE NOTATION :
T5N CSJ BMSWR DMVR BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12900 mg/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of esophagus
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84641 No. of Facilities: 193 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 9471 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84641 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR3249
RTECSTH8575000
Packaging GroupIII
Hazard Class6.1(b)
HS Code2935009090

Customs

HS Code2935009090
Summary2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles25

More Articles
[Experimental basis for the tentative permissible levels of phthalazol, sulfadimethoxine and Bepask in bodies of water].

Gig. Sanit. (12) , 9-10, (1993)

Tentative permissible levels (TPL) of phthalazol, sulfadimethoxine, and Bepask in the water were substantiated on the basis of study of organoleptic properties, of influence on sanitary status of wate...

The effect of antibacterial agents on the intestinal flora of patients: the use of aureomycin, chloromycetin, dihydrostreptomycin, sulfasuxidine and sulfathalidine.

Gastroenterology 16(1) , 12-8, (1950)

The effects of phthalylsulphathiazole on the bacteria of the colonic mucosa and intestinal contents as revealed by the examination of surgical samples.

Scand. J. Gastroenterol. 14(7) , 891-6, (1979)

The isolation of a bacterial flora specifically associated with the colonic mucosa of patients undergoing large-bowel surgery is described. This flora differed from that of faeces in both the numbers ...

Synonyms

Cremothalidine
Phthalylsulfathiazole
Taloudron
Ftalazol
2-[({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)carbonyl]benzoic acid
N-(4-thiazol-2-ylsulfamoyl-phenyl)-phthalamic acid
Talidine
entexidin
Phtalazol
N-(4-Thiazol-2-ylsulfamoyl-phenyl)-phthalamidsaeure
EINECS 201-627-4
Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]-
Sulftalyl
PST
2-[({4-[(2-thiazolylamino)sulfonyl]phenyl}amino)carbonyl]-benzoic acid
Thalinil
Ftalysept
2-{[4-(1,3-Thiazol-2-ylsulfamoyl)phenyl]carbamoyl}benzoic acid
MFCD00005318
Taleudron
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