Introduction：Basic information about CAS 145733-36-4|Tasosartan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tasosartan |
|---|
| CAS Number | 145733-36-4 | Molecular Weight | 411.459 |
|---|
| Density | 1.3±0.1 g/cm3 | Boiling Point | 759.4±70.0 °C at 760 mmHg |
|---|
| Molecular Formula | C23H21N7O | Melting Point | / |
|---|
| MSDS | / | Flash Point | 413.1±35.7 °C |
|---|
Names
| Name | 2,4-dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one |
|---|
| Synonym | More Synonyms |
|---|
Tasosartan BiologicalActivity
| Description | Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Angiotensin ReceptorResearch Areas >>Cardiovascular Disease |
|---|
| Target | Angiotensin II (AngII) receptor[1] |
|---|
| In Vitro | Tasosartan is an orally active nonpeptide AngII antagonist that has demonstrates specific and selective AT1 receptor antagonistic activity in vitro. IC50 for inhibition of specific binding of 125I-AngII to rat adrenal membrane in the absence of proteins in binding buffer is 1.2±0.6 nM[1]. |
|---|
| In Vivo | Administration of Tasosartan at doses of 1.0 and 3.0 mg/kg (iv) significantly (p<0.05) attenuates the pressor response to angiotensin-II in rats[2]. |
|---|
| Animal Admin | Rats[2] Pressor response to angiotensin-II administration in four groups of rats (n=3-5 each, weighing 343±8 g). Each rat is subjected to four separate bolus injections of angiotensin-II following the introduction of either the vehicle or graded doses of Tasosartan (0.3, 1.0, or 3.0 mg/kg, iv)[2]. |
|---|
| References | [1]. Maillard MP, et al. Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding. J Pharmacol Exp Ther. 2000 Nov;295(2):649-54. [2]. Elokdah HM, et al. Novel human metabolites of the angiotensin-II antagonist Tasosartan and their pharmacological effects. Bioorg Med Chem Lett. 2002 Aug 5;12(15):1967-71. |
|---|
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|
| Boiling Point | 759.4±70.0 °C at 760 mmHg |
|---|
| Molecular Formula | C23H21N7O |
|---|
| Molecular Weight | 411.459 |
|---|
| Flash Point | 413.1±35.7 °C |
|---|
| Exact Mass | 411.180756 |
|---|
| PSA | 100.55000 |
|---|
| LogP | 2.62 |
|---|
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
|---|
| Index of Refraction | 1.665 |
|---|
| InChIKey | ADXGNEYLLLSOAR-UHFFFAOYSA-N |
|---|
| SMILES | Cc1nc(C)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 |
|---|
| Storage condition | 2-8℃ |
|---|
Synonyms
| 2,4-dimethyl-8-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one |
| ANA-756 |
| 2,4-Dimethyl-8-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one |
| Pyrido[2,3-d]pyrimidin-7(6H)-one, 5,8-dihydro-2,4-dimethyl-8-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- |
| 2,4-Dimethyl-8-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one |
| 2,4-dimethyl-5,6,8-trihydro-8-[[2'-(1H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one |
| 2,4-dimethyl-8-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one |
| 8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl-methyl]-2,4-dimethyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one |
| Tasosartan (USAN/INN) |
| WAY-ANA-756 |
| S1539_Selleck |
| Verdia |
| tasosartan |
