CAS 86050-77-3|Gadopentetate dimeglumine

Introduction：Basic information about CAS 86050-77-3|Gadopentetate dimeglumine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Gadopentetate dimeglumine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Gadopentetate dimeglumine
CAS Number	86050-77-3	Molecular Weight	938.000
Density	/	Boiling Point	/
Molecular Formula	C₂₈H₅₄GdN₅O₂₀	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	gadopentetate dimeglumine
Synonym	More Synonyms

Gadopentetate dimeglumine BiologicalActivity

Description	Gadopentetate dimeglumine (SH-L-451A) is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Others
In Vitro	Gadobenate dimeglumine-enhanced MRI significantly improves cancer detection compared to gadopentetate dimeglumine-enhanced MRI, mammography, and ultrasound in a selected group of patients undergoing breast MRI for preoperative staging or because of inconclusive findings at conventional imaging[1]. Interstitial MR lymphography with gadopentetate dimeglumine (Gd-DTPA) or gadoxetate disodium (Gd-EOB-DTPA) allows clear visualization of the lymphatic pathway in healthy mice, and no significant difference is found between the two agents. Their rapid kinetics limits the imaging timing window, however, facilitates repeated assessment in a single imaging session[2]. Direct visualization of spilled gastrointestinal gadopentetate dimeglumine helps discriminate ischemic from control rats in this model[3].
Animal Admin	Rats: Twenty-eight rats are anesthetized and midline laparotomy is performed. Animals are divided into four groups: control, ligation of a single mesenteric arcade, ligation of six consecutive arcades, and ligation of the anterior mesenteric artery (analogous to the superior mesenteric artery in humans). A 1.0-mL enteric bolus of gadopentetate dimeglumine diluted with sterile water (1:1) is given via gavage. Magnetic resonance imaging is performed 2 hr after laparotomy and reviewed for the presence of intraperitoneal gadopentetate dimeglumine by two experienced observers. Animals are sacrificed 24 hr after surgery for pathologic examination[3]. Mice: MR lymphography are performed after the subcutaneous injection of gadopentetate dimeglumine (Gd-DTPA) or gadoxetate disodium (Gd-EOB-DTPA) (0.1, 0.5, or 2.0 mmol per mouse) into the right footpad in six healthy mice, and the time courses of contrast enhancement are assessed. Additionally, the lymphatic pathways from two distinct sites are assessed in tandem by interstitial MR lymphography studies[2].
References	[1]. Gilbert FJ, et al. Comparison of gadobenate dimeglumine-enhanced breast MRI and gadopentetate dimeglumine-enhanced breast MRI with mammography and ultrasound for the detection of breast cancer. J Magn Reson Imaging. 2014 May;39(5):1272-86. [2]. Sheng F, et al. Interstitial MR lymphography in mice with gadopentetate dimeglumine and gadoxetate disodium. J Magn Reson Imaging. 2011 Feb;33(2):490-7. [3]. Montalbano JM, et al. Magnetic resonance imaging detection of extraluminal enterally administered gadopentetate dimeglumine in a rat model of intestinal ischemia. Acad Radiol. 1996 Jun;3(6):486-92.

Chemical & Physical Properties

Molecular Formula	C₂₈H₅₄GdN₅O₂₀
Molecular Weight	938.000
Exact Mass	938.260315
PSA	389.58000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW1001000

CAS REGISTRY NUMBER :: 86050-77-3

LAST UPDATED :: 199412

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H18-Gd-N3-O10.2C7-H17-N-O5.2H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9411 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAJRDX AJR, American Journal of Roentgenology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.126- 1976- Volume(issue)/page/year: 142,619,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 612 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAJRDX AJR, American Journal of Roentgenology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.126- 1976- Volume(issue)/page/year: 142,619,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4291 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: (Suppl),254,1992

Synonyms

Meglumine gadopentetate

Gadopentetic acid dimeglumine salt

Gadolinium-DTPA

GADOPENTETATE DIMEGLUMINE

2-[bis[2-[carboxylatomethyl(carboxymethyl)amino]ethyl]amino]acetate,gadolinium(3+),(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol

Gd-DTPA

Dimeglumine-gadolinium-dtpa

Magnevist

Gadolinium (bis{2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl}amino)acetate - (2R,3R,4R,5S)-6-(methylamino)-1,2,3,4,5-hexanepentol (1:1:2)

Gadopentetate dimeglumine (JAN/USP)

Gadolinium dtpa

Diethylenetriaminepentaacetic acid dimeglumine salt gadolinium chelate

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