CAS 143545-90-8|epicylindrospermopsin

Introduction：Basic information about CAS 143545-90-8|epicylindrospermopsin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. epicylindrospermopsin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	epicylindrospermopsin
CAS Number	143545-90-8	Molecular Weight	415.422
Density	2.0±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₅H₂₁N₅O₇S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	cylindrospermopsin
Synonym	More Synonyms

epicylindrospermopsin BiologicalActivity

Description	Cylindrospermopsin is a cyanotoxin produced by a variety of freshwater cyanobacteria. It is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA[1].
Related Catalog	Signaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Others
References	[1]. I R Falconer, et al. Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin. Environ Toxicol. 2001;16(2):192-5.

Chemical & Physical Properties

Density	2.0±0.1 g/cm3
Molecular Formula	C₁₅H₂₁N₅O₇S
Molecular Weight	415.422
Exact Mass	415.116180
PSA	185.56000
LogP	-1.22
Appearance of Characters	white powder
Index of Refraction	1.858
Storage condition	−20°C
Water Solubility	DMSO: soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV9104310

CHEMICAL NAME :: 2,4(1H,3H)-Pyrimidinedione, 6-(hydroxy(2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(su lfooxy)- 1H-1,8,8b-triazaacenaphthylen-7-yl)methyl)-, (2a-alpha,3-alpha,4-alpha,5a- alpha,7-beta(R*))-(-)-

CAS REGISTRY NUMBER :: 143545-90-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H21-N5-O7-S

MOLECULAR WEIGHT :: 415.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 ug/kg

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - other changes Blood - changes in spleen

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,211,1994

Safety Information

WGK Germany	3
RTECS	UV9104310

Synonyms

(2aR,3S,4R,5aR,7S)-7-[(R)-(2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)(hydroxy)methyl]-3-methyl-2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylen-4-yl hydrogen sulfate

2,4(1H,3H)-Pyrimidinedione, 6-[(R)-hydroxy[(2aR,3S,4R,5aR,7S)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-

(2aS,3R,4S,5aS,7R)-7-[(S)-(2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)(hydroxy)methyl]-3-methyl-2a,3,4,5,5a,6,7,8-octahydro-2H-1,8,8b-triazaacenaphthylen-4-yl hydrogen sulfate

(2aR,3S,4R,5aR,7S)-7-[(R)-(2,6-Dihydroxy-4-pyrimidinyl)(hydroxy)methyl]-3-methyl-2a,3,4,5,5a,6,7,8-octahydro-2H-1,8,8b-triazaacenaphthylen-4-yl hydrogen sulfate

2,4(1H,3H)-Pyrimidinedione, 6-[(S)-hydroxy[(2aS,3R,4S,5aS,7R)-2a,3,4,5,5a,6,7,8-octahydro-3-methyl-4-(sulfooxy)-2H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-

7-epicyclindrospermopsin

Cylindrospermopsin

epicylindrospermopsin

2,4(1h,3h)-pyrimidinedione,6-(hydroxy(2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(

2,4-Pyrimidinediol, 6-[(R)-hydroxy[(2aR,3S,4R,5aR,7S)-2a,3,4,5,5a,6,7,8-octahydro-3-methyl-4-(sulfooxy)-2H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-

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