CAS 51798-45-9|Elastatinal
| Common Name | Elastatinal | ||
|---|---|---|---|
| CAS Number | 51798-45-9 | Molecular Weight | 512.56 |
| Density | 1.44 g/cm3 | Boiling Point | / |
| Molecular Formula | C21H36N8O7 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | elastatinal |
|---|---|
| Synonym | More Synonyms |
Elastatinal BiologicalActivity
| Description | Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease[1][2][3][4]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>ElastaseResearch Areas >>Inflammation/Immunology |
| In Vitro | Elastatinal inhibits the binding of acetyl-alanyl-alanyl-alanine pnitroanilide and acetyl-alanyl-alanyl-alanine methyl ester to elastase, with Kis of 0.24 μM and 0.21 μM, respectively[1]. Elastatinal (5-20 μM) suppresses the enhanced osteoclast differentiation by neutrophils[3]. |
| References | [1]. Umezawa H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 1976;45:678-95. [2]. Feinstein G, et, al. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys Acta. 1976 May 13;429(3):925-32. [3]. Sugisaki R, et, al. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. 2020 Mar;132:115216. [4]. Vidhya R, et, al. Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacol Immunotoxicol. 2020 Oct;42(5):423-435. |
Chemical & Physical Properties
| Density | 1.44 g/cm3 |
|---|---|
| Molecular Formula | C21H36N8O7 |
| Molecular Weight | 512.56 |
| Exact Mass | 496.27600 |
| PSA | 224.47000 |
| LogP | 0.62920 |
| Index of Refraction | 1.635 |
| Storage condition | −20°C |
| Water Solubility | H2O: 20 mg/mL, clear, yellow |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PPTCBY Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 6,57,1976
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | LZ9600000 |
Preparation
Articles18
More Articles| Elastatinal and leupeptin: effects on u.v.-induced mutation and sister-chromatid exchanges in Chinese hamster cells. Carcinogenesis 2(4) , 255-9, (1981) Microbial protease inhibitors elastatinal and leupeptin were tested for cytotoxicity and for effects on spontaneous and u.v.-induced 6-thioguanine-resistant (6TGr) mutation and sister-chromatid exchan... | |
| Reduction of active elastase concentration by means of immobilized inhibitors: a novel therapeutic approach. Biotechnol. Prog. 20(3) , 968-74, (2004) The inhibitory power of three different active Nylon membranes, separately loaded with three different protease inhibitors, was studied with the aim of reducing the increased elastase concentration oc... | |
| Effects of inhibitors of membrane signal peptide peptidase on protein translocation into membrane vesicles. Arch. Microbiol. 153(1) , 90-4, (1989) The effect of the removal of signal peptides after cleavage of precursor molecules by the signal peptidase I was examined in an in vitro translocation system with Escherichia coli membrane vesicles. T... |
Synonyms
| elastatinal from microbial source |
| Leu-co-cpd-Gln-Ala-h |
| Elastatinal |
| EINECS 257-426-7 |
