CAS 1476-98-8|TCMDC-125509

Introduction：Basic information about CAS 1476-98-8|TCMDC-125509, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Articles25
6. Synonyms

Common Name	TCMDC-125509
CAS Number	1476-98-8	Molecular Weight	362.894
Density	1.2g/cm3	Boiling Point	498.4ºC at 760mmHg
Molecular Formula	C₂₀H₂₇ClN₂O₂	Melting Point	277-279ºC(lit.)
MSDS	ChineseUSA	Flash Point	255.2ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	hydroquinidine hydrochloride
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.2g/cm3
Boiling Point	498.4ºC at 760mmHg
Melting Point	277-279ºC(lit.)
Molecular Formula	C₂₀H₂₇ClN₂O₂
Molecular Weight	362.894
Flash Point	255.2ºC
Exact Mass	362.176117
PSA	45.59000
LogP	4.13710
Vapour Pressure	9.92E-12mmHg at 25°C
InChIKey	MULXTQKDWYBJMO-VJAUXQICSA-N
SMILES	CCC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX3018000

CHEMICAL NAME :: Hydroquinidine, monohydrochloride

CAS REGISTRY NUMBER :: 1476-98-8

LAST UPDATED :: 199312

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H26-N2-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 369 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36
RIDADR	UN 1544
RTECS	MX3018000
Packaging Group	III
Hazard Class	6.1(b)

Articles25

Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.

Antimicrob. Agents Chemother. 56(10) , 5356-64, (2012)

The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and ...

Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent).

J. Org. Chem. 77(16) , 7076-80, (2012)

A first approach for catalytic asymmetric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using hydroquinine as chiral catalyst was developed. The catalytic sy...

Calculation of standard electrode potential of half reaction for benzoquinone and hydroquinone.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 65(2) , 333-9, (2006)

Geometric parameters, the vibrational frequencies and thermochemical values of benzoquinone and hydroquinone were computed using ab initio molecular orbital calculations (HF) and density function theo...

Synonyms

hydroquinidine,monohydrochloride

Einecs 216-024-1

dihydrochinidinhydrochlorid

(9S)-6'-Methoxy-10,11-dihydrocinchonan-9-ol hydrochloride (1:1)

Hydroquinidine Hydrochloride

Hydroquindine Hydrochloride

Hydroquinidine HCl

TCMDC-125509

MFCD00135598

Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-, hydrochloride (1:1)

Dihydroquinidine Hydrochloride

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