Introduction：Basic information about CAS 86770-74-3|Amino-PEG4-alcohol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amino-PEG4-alcohol |
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| CAS Number | 86770-74-3 | Molecular Weight | 193.241 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 301.6±27.0 °C at 760 mmHg |
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| Molecular Formula | C8H19NO4 | Melting Point | / |
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| MSDS | / | Flash Point | 136.2±23.7 °C |
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Names
| Name | 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol |
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| Synonym | More Synonyms |
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Amino-PEG4-alcohol BiologicalActivity
| Description | Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs Non-cleavable |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
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| References | [1]. Nello Mainolfi, et al. Protein degraders and uses thereof. WO2019060742A1. [2]. Miller MA, et al. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 Dec 26;12(12):12814-12826. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 301.6±27.0 °C at 760 mmHg |
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| Molecular Formula | C8H19NO4 |
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| Molecular Weight | 193.241 |
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| Flash Point | 136.2±23.7 °C |
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| Exact Mass | 193.131409 |
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| PSA | 73.94000 |
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| LogP | -2.09 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.459 |
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| InChIKey | ANOJXMUSDYSKET-UHFFFAOYSA-N |
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| SMILES | NCCOCCOCCOCCO |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- KJ6137500
- CHEMICAL NAME :
- Ethanol, 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-
- CAS REGISTRY NUMBER :
- 86770-74-3
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C8-H19-N-O4
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >8 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570546
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Safety Information
Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethanol |
| 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol |
| Ethanol, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]- |
