CAS 51-59-2|N-Acetyl Mesalazine
| Common Name | N-Acetyl Mesalazine | ||
|---|---|---|---|
| CAS Number | 51-59-2 | Molecular Weight | 195.17 |
| Density | 1.462 g/cm3 | Boiling Point | 480.2ºC at 760 mmHg |
| Molecular Formula | C9H9NO4 | Melting Point | 228-230ºC |
| MSDS | ChineseUSA | Flash Point | 244.2ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 5-acetamido-2-hydroxybenzoic acid |
|---|---|
| Synonym | More Synonyms |
N-Acetyl Mesalazine BiologicalActivity
| Description | N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the metabolite of 5-Aminosalicylic Acid (HY-15027) with endoscopic activity. N-Acetyl mesalazine can be used for the research of ulcerative colitis[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| References | [1]. Allgayer H, et al. Modulation of base hydroxylation by bile acids and salicylates in a model of human colonic mucosal DNA: putative implications in colonic cancer. Dig Dis Sci. 1999 Apr;44(4):761-7. [2]. Fukuda T, et al. Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine. J Gastroenterol Hepatol. 2020 Nov;35(11):1878-1885. |
Chemical & Physical Properties
| Density | 1.462 g/cm3 |
|---|---|
| Boiling Point | 480.2ºC at 760 mmHg |
| Melting Point | 228-230ºC |
| Molecular Formula | C9H9NO4 |
| Molecular Weight | 195.17 |
| Flash Point | 244.2ºC |
| Exact Mass | 195.05300 |
| PSA | 86.63000 |
| LogP | 1.12180 |
| Index of Refraction | 1.661 |
| InChIKey | GEFDRROBUCULOD-UHFFFAOYSA-N |
| SMILES | CC(=O)Nc1ccc(O)c(C(=O)O)c1 |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2924299090 |
Customs
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles25
More Articles| Simultaneous determination of 5-aminosalicylic acid, acetyl-5-aminosalicylic acid and 2,5-dihydroxybenzoic acid in endoscopic intestinal biopsy samples in humans by high-performance liquid chromatography with electrochemical detection. J. Pharm. Biomed. Anal. 14(1-2) , 175-80, (1995) A high-performance liquid chromatographic method for the simultaneous determination of 5-aminosalicylic acid (5-ASA), acetyl-5-aminosalicylic acid (Ac-5-ASA) and 2,5-dihydroxybenzoic acid (5-HSA) in h... | |
| Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate active ulcerative colitis: results of a randomized, double-blind study. J. Pediatr. Gastroenterol. Nutr. 49(5) , 571-9, (2009) : A multicenter, double-blind study was conducted to evaluate the safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate ulcerative colitis (UC).: Sixty-eigh... | |
| Radical-derived oxidation products of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid. J. Chromatogr. B, Biomed. Appl. 661(1) , 57-68, (1994) 5-Aminosalicylic acid is an agent effective in the treatment of chronic inflammatory bowel diseases. Its ability to scavenge radicals is considered to be a major factor responsible for its therapeutic... |
Synonyms
| CJ 46A |
| N-Acetyl Mesalazine |
| 5-Acetamidosalicylic acid |
| N-Acetyl-5-aminosalicylic acid |
| 3-Carboxyparacetamol |
| 5-acetylamino salicylic acid |
| Acetylmesalazine 5-Acetamidosalicylic acid N-Acetyl-5-aminosalicylic acid |
| 5-acetamido-2-hydroxy-benzoic acid |
